| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 16 | CHW |  | 3 | 13 |  | CHC | May 16 02:20 PM EDT (Fri) | Wrigley Field |
| May 16 | CLE |  | 4 | 5 |  | CIN | May 16 05:10 PM EDT (Fri) | Great American Ball Park |
| May 16 | PIT |  | 4 | 8 |  | PHI | May 16 06:45 PM EDT (Fri) | Citizens Bank Park |
| May 16 | WAS |  | 4 | 3 |  | BAL | May 16 07:05 PM EDT (Fri) | Oriole Park at Camden Yards |
| May 16 | NYM |  | 2 | 6 |  | NYY | May 16 07:05 PM EDT (Fri) | Yankee Stadium |
| May 16 | DET |  | 5 | 4 |  | TOR | May 16 07:07 PM EDT (Fri) | Rogers Centre |
| May 16 | ATL |  | 4 | 2 |  | BOS | May 16 07:10 PM EDT (Fri) | Fenway Park |
| May 16 | TB |  | 4 | 9 |  | MIA | May 16 07:10 PM EDT (Fri) | loanDepot park |
| May 16 | STL |  | 10 | 3 |  | KC | May 16 07:40 PM EDT (Fri) | Kauffman Stadium |
| May 16 | HOU |  | 6 | 3 |  | TEX | May 16 08:05 PM EDT (Fri) | Globe Life Field |
| May 16 | MIN |  | 3 | 0 |  | MIL | May 16 08:10 PM EDT (Fri) | American Family Field |
| May 16 | COL |  | 0 | 8 |  | ARI | May 16 09:40 PM EDT (Fri) | Chase Field |
| May 16 | SEA |  | 5 | 1 |  | SD | May 16 09:40 PM EDT (Fri) | Petco Park |
| May 16 | LAA |  | 6 | 2 |  | LAD | May 16 10:10 PM EDT (Fri) | Dodger Stadium |
| May 16 | LV |  | 1 | 9 |  | SF | May 16 10:15 PM EDT (Fri) | Oracle Park |
