| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 21 | CIN |  | 1 | 3 |  | PIT | May 21 12:35 PM EDT (Wed) | PNC Park |
| May 21 | HOU |  | 4 | 8 |  | TB | May 21 01:10 PM EDT (Wed) | George M. Steinbrenner Field |
| May 21 | CLE |  | 5 | 1 |  | MIN | May 21 03:55 PM EDT (Wed) | Target Field |
| May 21 | CHC |  | 2 | 1 |  | MIA | May 21 01:10 PM EDT (Wed) | loanDepot park |
| May 21 | BAL |  | 8 | 4 |  | MIL | May 21 01:10 PM EDT (Wed) | American Family Field |
| May 21 | DET |  | 5 | 1 |  | STL | May 21 01:15 PM EDT (Wed) | Busch Stadium |
| May 21 | SEA |  | 6 | 5 |  | CHW | May 21 02:10 PM EDT (Wed) | Rate Field |
| May 21 | KC |  | 8 | 4 |  | SF | May 21 03:45 PM EDT (Wed) | Oracle Park |
| May 21 | NYM |  | 5 | 1 |  | BOS | May 21 06:45 PM EDT (Wed) | Fenway Park |
| May 21 | ATL |  | (postponed) |  | WAS | May 21 06:45 PM EDT (Wed) | Nationals Park (resch Sep 16) |
| May 21 | TEX |  | 3 | 4 |  | NYY | May 21 07:05 PM EDT (Wed) | Yankee Stadium |
| May 21 | SD |  | 0 | 14 |  | TOR | May 21 07:07 PM EDT (Wed) | Rogers Centre |
| May 21 | PHI |  | 9 | 5 |  | COL | May 21 08:40 PM EDT (Wed) | Coors Field |
| May 21 | LAA |  | 10 | 5 |  | LV | May 21 10:05 PM EDT (Wed) | Sutter Health Park |
| May 21 | ARI |  | 1 | 3 |  | LAD | May 21 10:10 PM EDT (Wed) | Dodger Stadium |
