| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 22 | NYY |  | 2 | 3 |  | CLE | Apr 22 06:10 PM EDT (Tue) | Progressive Field |
| Apr 22 | SD |  | 2 | 0 |  | DET | Apr 22 06:40 PM EDT (Tue) | Comerica Park |
| Apr 22 | CIN |  | 3 | 4 |  | MIA | Apr 22 06:40 PM EDT (Tue) | loanDepot park |
| Apr 22 | BAL |  | 0 | 7 |  | WAS | Apr 22 06:45 PM EDT (Tue) | Nationals Park |
| Apr 22 | SEA |  | 3 | 8 |  | BOS | Apr 22 06:45 PM EDT (Tue) | Fenway Park |
| Apr 22 | PHI |  | 1 | 5 |  | NYM | Apr 22 07:10 PM EDT (Tue) | Citi Field |
| Apr 22 | STL |  | 10 | 4 |  | ATL | Apr 22 07:15 PM EDT (Tue) | Truist Park |
| Apr 22 | COL |  | 3 | 4 |  | KC | Apr 22 07:40 PM EDT (Tue) | Kauffman Stadium |
| Apr 22 | LAD |  | 10 | 11 |  | CHC | Apr 22 07:40 PM EDT (Tue) | Wrigley Field |
| Apr 22 | CHW |  | 2 | 4 |  | MIN | Apr 22 07:40 PM EDT (Tue) | Target Field |
| Apr 22 | TOR |  | 1 | 5 |  | HOU | Apr 22 08:10 PM EDT (Tue) | Daikin Park |
| Apr 22 | PIT |  | 9 | 3 |  | LAA | Apr 22 09:38 PM EDT (Tue) | Angel Stadium |
| Apr 22 | TB |  | 1 | 5 |  | ARI | Apr 22 09:40 PM EDT (Tue) | Chase Field |
| Apr 22 | MIL |  | 11 | 3 |  | SF | Apr 22 09:45 PM EDT (Tue) | Oracle Park |
| Apr 22 | TEX |  | 8 | 5 |  | LV | Apr 22 10:05 PM EDT (Tue) | Sutter Health Park |
