| Clemson Schedule: (11-3 / 11-2 as favorite / 0-1 as underdog) ESPN Profile Page |
| Date |
Away |
Away Score |
|
Home Score |
Home |
Notes |
| 2021-09-04 12:00 Eastern |
#5 Georgia (+135) |  | 10 |
at |
3 |  | #3 Clemson (-155) |
Bank of America Stadium, Charlotte, NC |
| 2021-09-11 12:00 Eastern |
South Carolina State | | 3 |
at |
49 |  | #6 Clemson |
Memorial Stadium , Clemson, SC |
| 2021-09-18 12:00 Eastern |
Georgia Tech |  | 8 |
at |
14 |  | #6 Clemson |
Memorial Stadium , Clemson, SC |
| 2021-09-25 12:00 Eastern |
#9 Clemson (-380) |  | 21 |
at |
27 |  | NC State (+290) |
Carter-Finley Stadium, Raleigh, NC |
| 2021-10-02 12:00 Eastern |
Boston College (+600) |  | 13 |
at |
19 |  | #25 Clemson (-800) |
Memorial Stadium , Clemson, SC |
| 2021-10-15 19:00 Eastern |
Clemson (-550) |  | 17 |
at |
14 |  | Syracuse (+400) |
Carrier Dome, Syracuse, NY |
| 2021-10-23 12:00 Eastern |
Clemson (+150) |  | 17 |
at |
23 |  | #23 Pittsburgh (-170) |
Heinz Field, Pittsburgh, PA |
| 2021-10-30 12:00 Eastern |
Florida State (+290) |  | 20 |
at |
30 |  | Clemson (-380) |
Memorial Stadium , Clemson, SC |
| 2021-11-06 12:00 Eastern |
Clemson (-200) |  | 30 |
at |
24 |  | Louisville (+165) |
Cardinal Stadium, Louisville, KY |
| 2021-11-13 12:00 Eastern |
UConn |  | 7 |
at |
44 |  | Clemson |
Memorial Stadium , Clemson, SC |
| 2021-11-20 12:00 Eastern |
#10 Wake Forest (+150) |  | 27 |
at |
48 |  | Clemson (-170) |
Memorial Stadium , Clemson, SC |
| 2021-11-27 12:00 Eastern |
#23 Clemson (-550) |  | 30 |
at |
0 |  | South Carolina (+375) |
Williams-Brice Stadium, Columbia, SC |
| 2021-12-25 09:00 Eastern |
Clemson (-110) |  | 20 |
at |
13 |  | Iowa State (+105) |
- |
| 2021-12-29 17:45 Eastern |
#19 Clemson (-110) |  | 20 |
at |
13 |  | Iowa State (+105) |
Cheez-It Bowl |
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