| Louisville Schedule: (6-7 / 5-3 as favorite / 1-4 as underdog) ESPN Profile Page |
|---|
| Date |
Away |
Away Score |
|
Home Score |
Home |
Notes |
| 2021-09-04 12:00 Eastern |
Louisville (+290) |  | 24 |
at |
43 |  | Mississippi (-350) |
Mercedes-Benz Stadium, Atlanta, GA |
| 2021-09-11 12:00 Eastern |
Eastern Kentucky | | 3 |
at |
30 | | Louisville |
Cardinal Stadium, Louisville, KY |
| 2021-09-17 16:30 Eastern |
Central Florida (-275) |  | 35 |
at |
42 | | Louisville (+220) |
Cardinal Stadium, Louisville, KY |
| 2021-09-25 12:00 Eastern |
Louisville (-130) | | 31 |
at |
23 |  | Florida State (+110) |
Doak Campbell Stadium, Tallahassee, FL |
| 2021-10-02 12:00 Eastern |
Louisville (+210) | | 34 |
at |
37 |  | #24 Wake Forest (-260) |
Truist Field, Winston-Salem, NC |
| 2021-10-09 12:00 Eastern |
Virginia (+110) |  | 34 |
at |
33 | | Louisville (-130) |
Cardinal Stadium, Louisville, KY |
| 2021-10-23 12:00 Eastern |
Boston College (+190) |  | 14 |
at |
28 | | Louisville (-240) |
Cardinal Stadium, Louisville, KY |
| 2021-10-30 12:00 Eastern |
Louisville (+200) | | 13 |
at |
28 |  | NC State (-240) |
Carter-Finley Stadium, Raleigh, NC |
| 2021-11-06 12:00 Eastern |
Clemson (-200) |  | 30 |
at |
24 | | Louisville (+165) |
Cardinal Stadium, Louisville, KY |
| 2021-11-13 12:00 Eastern |
Syracuse (+135) |  | 7 |
at |
41 | | Louisville (-155) |
Cardinal Stadium, Louisville, KY |
| 2021-11-18 19:30 Eastern |
Louisville (-1200) | | 62 |
at |
22 |  | Duke (+700) |
Wallace Wade Stadium, Durham, NC |
| 2021-11-27 12:00 Eastern |
Kentucky (+120) |  | 52 |
at |
21 | | Louisville (-140) |
Cardinal Stadium, Louisville, KY |
| 2021-12-28 15:15 Eastern |
Air Force (+110) |  | 31 |
at |
28 | | Louisville (-125) |
SERVPROD Bowl |
|
