| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 01 | SF |  | 3 | 1 |  | HOU | Apr 01 08:10 PM EDT (Tue) | Daikin Park |
| Apr 02 | SF | | 6 | 3 | | HOU | Apr 02 04:10 PM EDT (Wed) | Daikin Park |
| Apr 03 | HOU | | 5 | 2 |  | MIN | Apr 03 04:10 PM EDT (Thu) | Target Field |
| Apr 05 | HOU | | 1 | 6 | | MIN | Apr 05 02:10 PM EDT (Sat) | Target Field |
| Apr 06 | HOU | | 9 | 7 | | MIN | Apr 06 02:10 PM EDT (Sun) | Target Field |
| Apr 07 | HOU | | 3 | 4 |  | SEA | Apr 07 09:40 PM EDT (Mon) | T-Mobile Park |
| Apr 08 | HOU | | 2 | 1 | | SEA | Apr 08 09:40 PM EDT (Tue) | T-Mobile Park |
| Apr 09 | HOU | | 6 | 7 | | SEA | Apr 09 04:10 PM EDT (Wed) | T-Mobile Park |
| Apr 11 | LAA |  | 3 | 14 | | HOU | Apr 11 08:10 PM EDT (Fri) | Daikin Park |
| Apr 12 | LAA | | 4 | 1 | | HOU | Apr 12 07:10 PM EDT (Sat) | Daikin Park |
| Apr 13 | LAA | | 3 | 7 | | HOU | Apr 13 02:10 PM EDT (Sun) | Daikin Park |
| Apr 14 | HOU | | 3 | 8 |  | STL | Apr 14 07:45 PM EDT (Mon) | Busch Stadium |
| Apr 15 | HOU | | 2 | 0 | | STL | Apr 15 07:45 PM EDT (Tue) | Busch Stadium |
| Apr 16 | HOU | | 1 | 4 | | STL | Apr 16 01:15 PM EDT (Wed) | Busch Stadium |
| Apr 18 | SD |  | 4 | 6 | | HOU | Apr 18 08:10 PM EDT (Fri) | Daikin Park |
| Apr 19 | SD | | 2 | 3 | | HOU | Apr 19 07:10 PM EDT (Sat) | Daikin Park |
| Apr 20 | SD | | 3 | 2 | | HOU | Apr 20 07:10 PM EDT (Sun) | Daikin Park |
| Apr 21 | TOR |  | 0 | 7 | | HOU | Apr 21 08:10 PM EDT (Mon) | Daikin Park |
| Apr 22 | TOR | | 1 | 5 | | HOU | Apr 22 08:10 PM EDT (Tue) | Daikin Park |
| Apr 23 | TOR | | 1 | 3 | | HOU | Apr 23 07:40 PM EDT (Wed) | Daikin Park |
| Apr 25 | HOU | | 0 | 2 |  | KC | Apr 25 07:40 PM EDT (Fri) | Kauffman Stadium |
| Apr 26 | HOU | | 0 | 2 | | KC | Apr 26 07:10 PM EDT (Sat) | Kauffman Stadium |
| Apr 27 | HOU | | 7 | 3 | | KC | Apr 27 02:10 PM EDT (Sun) | Kauffman Stadium |
| Apr 28 | DET |  | 5 | 8 | | HOU | Apr 28 08:10 PM EDT (Mon) | Daikin Park |
| Apr 29 | DET | | 4 | 6 | | HOU | Apr 29 08:10 PM EDT (Tue) | Daikin Park |
| Apr 30 | DET | | 7 | 4 | | HOU | Apr 30 02:10 PM EDT (Wed) | Daikin Park |
