| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 01 | PIT |  | 0 | 7 |  | TB | Apr 01 07:05 PM EDT (Tue) | George M. Steinbrenner Field |
| Apr 02 | PIT | | 4 | 2 | | TB | Apr 02 01:10 PM EDT (Wed) | George M. Steinbrenner Field |
| Apr 04 | NYY |  | 9 | 4 | | PIT | Apr 04 04:12 PM EDT (Fri) | PNC Park |
| Apr 05 | NYY | | 10 | 4 | | PIT | Apr 05 04:05 PM EDT (Sat) | PNC Park |
| Apr 06 | NYY | | 4 | 5 | | PIT | Apr 06 01:35 PM EDT (Sun) | PNC Park |
| Apr 07 | STL |  | 4 | 8 | | PIT | Apr 07 06:40 PM EDT (Mon) | PNC Park |
| Apr 08 | STL | | 5 | 3 | | PIT | Apr 08 06:40 PM EDT (Tue) | PNC Park |
| Apr 09 | STL | | 1 | 2 | | PIT | Apr 09 12:35 PM EDT (Wed) | PNC Park |
| Apr 11 | PIT | | 3 | 5 |  | CIN | Apr 11 06:40 PM EDT (Fri) | Great American Ball Park |
| Apr 12 | PIT | | 2 | 5 | | CIN | Apr 12 06:40 PM EDT (Sat) | Great American Ball Park |
| Apr 13 | PIT | | 0 | 4 | | CIN | Apr 13 01:40 PM EDT (Sun) | Great American Ball Park |
| Apr 14 | WAS |  | 3 | 10 | | PIT | Apr 14 06:40 PM EDT (Mon) | PNC Park |
| Apr 15 | WAS | | 3 | 0 | | PIT | Apr 15 06:40 PM EDT (Tue) | PNC Park |
| Apr 16 | WAS | | 1 | 6 | | PIT | Apr 16 06:40 PM EDT (Wed) | PNC Park |
| Apr 17 | WAS | | 0 | 1 | | PIT | Apr 17 12:35 PM EDT (Thu) | PNC Park |
| Apr 18 | CLE |  | 10 | 7 | | PIT | Apr 18 06:40 PM EDT (Fri) | PNC Park |
| Apr 19 | CLE | | 3 | 0 | | PIT | Apr 19 04:05 PM EDT (Sat) | PNC Park |
| Apr 20 | CLE | | 5 | 4 | | PIT | Apr 20 01:35 PM EDT (Sun) | PNC Park |
| Apr 22 | PIT | | 9 | 3 |  | LAA | Apr 22 09:38 PM EDT (Tue) | Angel Stadium |
| Apr 23 | PIT | | 3 | 0 | | LAA | Apr 23 09:38 PM EDT (Wed) | Angel Stadium |
| Apr 24 | PIT | | 3 | 4 | | LAA | Apr 24 09:29 PM EDT (Thu) | Angel Stadium |
| Apr 25 | PIT | | 3 | 0 |  | LAD | Apr 25 10:10 PM EDT (Fri) | Dodger Stadium |
| Apr 26 | PIT | | 4 | 8 | | LAD | Apr 26 09:10 PM EDT (Sat) | Dodger Stadium |
| Apr 27 | PIT | | 2 | 9 | | LAD | Apr 27 04:10 PM EDT (Sun) | Dodger Stadium |
| Apr 29 | CHC |  | 9 | 0 | | PIT | Apr 29 06:40 PM EDT (Tue) | PNC Park |
| Apr 30 | CHC | | 3 | 4 | | PIT | Apr 30 06:40 PM EDT (Wed) | PNC Park |
