| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 01 | DET |  | 4 | 1 |  | SEA | Apr 01 09:40 PM EDT (Tue) | T-Mobile Park |
| Apr 02 | DET | | 2 | 3 | | SEA | Apr 02 04:10 PM EDT (Wed) | T-Mobile Park |
| Apr 04 | SEA | | 9 | 10 |  | SF | Apr 04 04:35 PM EDT (Fri) | Oracle Park |
| Apr 05 | SEA | | 1 | 4 | | SF | Apr 05 09:05 PM EDT (Sat) | Oracle Park |
| Apr 06 | SEA | | 4 | 5 | | SF | Apr 06 04:05 PM EDT (Sun) | Oracle Park |
| Apr 07 | HOU |  | 3 | 4 | | SEA | Apr 07 09:40 PM EDT (Mon) | T-Mobile Park |
| Apr 08 | HOU | | 2 | 1 | | SEA | Apr 08 09:40 PM EDT (Tue) | T-Mobile Park |
| Apr 09 | HOU | | 6 | 7 | | SEA | Apr 09 04:10 PM EDT (Wed) | T-Mobile Park |
| Apr 11 | TEX |  | 3 | 5 | | SEA | Apr 11 09:40 PM EDT (Fri) | T-Mobile Park |
| Apr 12 | TEX | | 2 | 9 | | SEA | Apr 12 09:40 PM EDT (Sat) | T-Mobile Park |
| Apr 13 | TEX | | 1 | 3 | | SEA | Apr 13 04:10 PM EDT (Sun) | T-Mobile Park |
| Apr 15 | SEA | | 4 | 8 |  | CIN | Apr 15 06:40 PM EDT (Tue) | Great American Ball Park |
| Apr 16 | SEA | | 5 | 3 | | CIN | Apr 16 06:40 PM EDT (Wed) | Great American Ball Park |
| Apr 17 | SEA | | 11 | 7 | | CIN | Apr 17 12:40 PM EDT (Thu) | Great American Ball Park |
| Apr 18 | SEA | | 1 | 3 |  | TOR | Apr 18 07:07 PM EDT (Fri) | Rogers Centre |
| Apr 19 | SEA | | 8 | 4 | | TOR | Apr 19 03:07 PM EDT (Sat) | Rogers Centre |
| Apr 20 | SEA | | 8 | 3 | | TOR | Apr 20 01:37 PM EDT (Sun) | Rogers Centre |
| Apr 22 | SEA | | 3 | 8 |  | BOS | Apr 22 06:45 PM EDT (Tue) | Fenway Park |
| Apr 23 | SEA | | 8 | 5 | | BOS | Apr 23 06:45 PM EDT (Wed) | Fenway Park |
| Apr 24 | SEA | | 4 | 3 | | BOS | Apr 24 01:35 PM EDT (Thu) | Fenway Park |
| Apr 25 | MIA |  | 8 | 4 | | SEA | Apr 25 09:40 PM EDT (Fri) | T-Mobile Park |
| Apr 26 | MIA | | 0 | 14 | | SEA | Apr 26 09:40 PM EDT (Sat) | T-Mobile Park |
| Apr 27 | MIA | | 6 | 7 | | SEA | Apr 27 04:10 PM EDT (Sun) | T-Mobile Park |
| Apr 29 | LAA |  | 3 | 5 | | SEA | Apr 29 09:40 PM EDT (Tue) | T-Mobile Park |
| Apr 30 | LAA | | 3 | 9 | | SEA | Apr 30 04:10 PM EDT (Wed) | T-Mobile Park |
