| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 01 | SF |  | 3 | 1 |  | HOU | Apr 01 08:10 PM EDT (Tue) | Daikin Park |
| Apr 02 | SF | | 6 | 3 | | HOU | Apr 02 04:10 PM EDT (Wed) | Daikin Park |
| Apr 04 | SEA |  | 9 | 10 | | SF | Apr 04 04:35 PM EDT (Fri) | Oracle Park |
| Apr 05 | SEA | | 1 | 4 | | SF | Apr 05 09:05 PM EDT (Sat) | Oracle Park |
| Apr 06 | SEA | | 4 | 5 | | SF | Apr 06 04:05 PM EDT (Sun) | Oracle Park |
| Apr 07 | CIN |  | 2 | 0 | | SF | Apr 07 09:45 PM EDT (Mon) | Oracle Park |
| Apr 08 | CIN | | 1 | 0 | | SF | Apr 08 09:45 PM EDT (Tue) | Oracle Park |
| Apr 09 | CIN | | 6 | 8 | | SF | Apr 09 03:45 PM EDT (Wed) | Oracle Park |
| Apr 11 | SF | | 9 | 1 |  | NYY | Apr 11 07:05 PM EDT (Fri) | Yankee Stadium |
| Apr 12 | SF | | 4 | 8 | | NYY | Apr 12 03:05 PM EDT (Sat) | Yankee Stadium |
| Apr 13 | SF | | 5 | 4 | | NYY | Apr 13 01:35 PM EDT (Sun) | Yankee Stadium |
| Apr 14 | SF | | 10 | 4 |  | PHI | Apr 14 06:45 PM EDT (Mon) | Citizens Bank Park |
| Apr 15 | SF | | 4 | 6 | | PHI | Apr 15 06:45 PM EDT (Tue) | Citizens Bank Park |
| Apr 16 | SF | | 11 | 4 | | PHI | Apr 16 06:45 PM EDT (Wed) | Citizens Bank Park |
| Apr 17 | SF | | 4 | 6 | | PHI | Apr 17 04:05 PM EDT (Thu) | Citizens Bank Park |
| Apr 18 | SF | | 0 | 2 |  | LAA | Apr 18 09:38 PM EDT (Fri) | Angel Stadium |
| Apr 19 | SF | | 3 | 2 | | LAA | Apr 19 09:38 PM EDT (Sat) | Angel Stadium |
| Apr 20 | SF | | 4 | 5 | | LAA | Apr 20 04:07 PM EDT (Sun) | Angel Stadium |
| Apr 21 | MIL |  | 2 | 5 | | SF | Apr 21 09:45 PM EDT (Mon) | Oracle Park |
| Apr 22 | MIL | | 11 | 3 | | SF | Apr 22 09:45 PM EDT (Tue) | Oracle Park |
| Apr 23 | MIL | | 2 | 4 | | SF | Apr 23 09:45 PM EDT (Wed) | Oracle Park |
| Apr 24 | MIL | | 5 | 6 | | SF | Apr 24 03:45 PM EDT (Thu) | Oracle Park |
| Apr 25 | TEX |  | 2 | 0 | | SF | Apr 25 10:15 PM EDT (Fri) | Oracle Park |
| Apr 26 | TEX | | 2 | 3 | | SF | Apr 26 04:05 PM EDT (Sat) | Oracle Park |
| Apr 27 | TEX | | 2 | 3 | | SF | Apr 27 04:05 PM EDT (Sun) | Oracle Park |
| Apr 29 | SF | | 4 | 7 |  | SD | Apr 29 09:40 PM EDT (Tue) | Petco Park |
| Apr 30 | SF | | 3 | 5 | | SD | Apr 30 04:10 PM EDT (Wed) | Petco Park |
