| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 01 | STL |  | 1 | 9 |  | CIN | May 01 12:40 PM EDT (Thu) | Great American Ball Park |
| May 02 | WAS |  | 1 | 6 | | CIN | May 02 06:10 PM EDT (Fri) | Great American Ball Park |
| May 03 | WAS | | 11 | 6 | | CIN | May 03 06:40 PM EDT (Sat) | Great American Ball Park |
| May 04 | WAS | | 4 | 1 | | CIN | May 04 04:10 PM EDT (Sun) | Great American Ball Park |
| May 05 | CIN | | 0 | 4 |  | ATL | May 05 07:15 PM EDT (Mon) | Truist Park |
| May 06 | CIN | | 1 | 2 | | ATL | May 06 07:15 PM EDT (Tue) | Truist Park |
| May 07 | CIN | | 4 | 3 | | ATL | May 07 07:15 PM EDT (Wed) | Truist Park |
| May 08 | CIN | | 4 | 5 | | ATL | May 08 07:15 PM EDT (Thu) | Truist Park |
| May 09 | CIN | | 0 | 3 |  | HOU | May 09 08:10 PM EDT (Fri) | Daikin Park |
| May 10 | CIN | | 13 | 9 | | HOU | May 10 07:10 PM EDT (Sat) | Daikin Park |
| May 11 | CIN | | 0 | 6 | | HOU | May 11 02:10 PM EDT (Sun) | Daikin Park |
| May 13 | CHW |  | 5 | 1 | | CIN | May 13 06:40 PM EDT (Tue) | Great American Ball Park |
| May 14 | CHW | | 4 | 2 | | CIN | May 14 07:14 PM EDT (Wed) | Great American Ball Park |
| May 15 | CHW | | 1 | 7 | | CIN | May 15 12:40 PM EDT (Thu) | Great American Ball Park |
| May 16 | CLE |  | 4 | 5 | | CIN | May 16 05:10 PM EDT (Fri) | Great American Ball Park |
| May 17 | CLE | | 1 | 4 | | CIN | May 17 06:40 PM EDT (Sat) | Great American Ball Park |
| May 18 | CLE | | 1 | 3 | | CIN | May 18 01:40 PM EDT (Sun) | Great American Ball Park |
| May 19 | CIN | | 7 | 1 |  | PIT | May 19 06:40 PM EDT (Mon) | PNC Park |
| May 20 | CIN | | 0 | 1 | | PIT | May 20 06:40 PM EDT (Tue) | PNC Park |
| May 21 | CIN | | 1 | 3 | | PIT | May 21 12:35 PM EDT (Wed) | PNC Park |
| May 23 | CHC |  | 13 | 6 | | CIN | May 23 06:40 PM EDT (Fri) | Great American Ball Park |
| May 24 | CHC | | 4 | 6 | | CIN | May 24 04:10 PM EDT (Sat) | Great American Ball Park |
| May 25 | CHC | | 11 | 8 | | CIN | May 25 01:40 PM EDT (Sun) | Great American Ball Park |
| May 26 | CIN | | 7 | 4 |  | KC | May 26 04:10 PM EDT (Mon) | Kauffman Stadium |
| May 27 | CIN | | 7 | 2 | | KC | May 27 07:40 PM EDT (Tue) | Kauffman Stadium |
| May 28 | CIN | | 2 | 3 | | KC | May 28 07:40 PM EDT (Wed) | Kauffman Stadium |
| May 30 | CIN | | 6 | 2 | | CHC | May 30 02:20 PM EDT (Fri) | Wrigley Field |
| May 31 | CIN | | 0 | 2 | | CHC | May 31 02:20 PM EDT (Sat) | Wrigley Field |
