| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 01 | COL |  | 4 | 3 |  | SF | May 01 09:45 PM EDT (Thu) | Oracle Park |
| May 02 | COL | | 0 | 4 | | SF | May 02 10:15 PM EDT (Fri) | Oracle Park |
| May 03 | COL | | 3 | 6 | | SF | May 03 04:05 PM EDT (Sat) | Oracle Park |
| May 04 | COL | | 3 | 9 | | SF | May 04 04:05 PM EDT (Sun) | Oracle Park |
| May 05 | SF | | 2 | 9 |  | CHC | May 05 07:40 PM EDT (Mon) | Wrigley Field |
| May 06 | SF | | 14 | 5 | | CHC | May 06 07:40 PM EDT (Tue) | Wrigley Field |
| May 07 | SF | | 3 | 1 | | CHC | May 07 02:20 PM EDT (Wed) | Wrigley Field |
| May 09 | SF | | 1 | 3 |  | MIN | May 09 08:10 PM EDT (Fri) | Target Field |
| May 10 | SF | | 1 | 2 | | MIN | May 10 07:15 PM EDT (Sat) | Target Field |
| May 11 | SF | | 6 | 7 | | MIN | May 11 02:10 PM EDT (Sun) | Target Field |
| May 12 | ARI |  | 2 | 1 | | SF | May 12 09:45 PM EDT (Mon) | Oracle Park |
| May 13 | ARI | | 6 | 10 | | SF | May 13 09:45 PM EDT (Tue) | Oracle Park |
| May 14 | ARI | | 8 | 7 | | SF | May 14 03:45 PM EDT (Wed) | Oracle Park |
| May 16 | LV |  | 1 | 9 | | SF | May 16 10:15 PM EDT (Fri) | Oracle Park |
| May 17 | LV | | 0 | 1 | | SF | May 17 09:05 PM EDT (Sat) | Oracle Park |
| May 18 | LV | | 2 | 3 | | SF | May 18 04:05 PM EDT (Sun) | Oracle Park |
| May 19 | KC |  | 3 | 1 | | SF | May 19 09:45 PM EDT (Mon) | Oracle Park |
| May 20 | KC | | 2 | 3 | | SF | May 20 09:45 PM EDT (Tue) | Oracle Park |
| May 21 | KC | | 8 | 4 | | SF | May 21 03:45 PM EDT (Wed) | Oracle Park |
| May 23 | SF | | 4 | 0 |  | WAS | May 23 06:45 PM EDT (Fri) | Nationals Park |
| May 24 | SF | | 0 | 3 | | WAS | May 24 04:05 PM EDT (Sat) | Nationals Park |
| May 25 | SF | | 3 | 2 | | WAS | May 25 01:35 PM EDT (Sun) | Nationals Park |
| May 26 | SF | | 1 | 3 |  | DET | May 26 01:10 PM EDT (Mon) | Comerica Park |
| May 27 | SF | | 1 | 3 | | DET | May 27 06:40 PM EDT (Tue) | Comerica Park |
| May 28 | SF | | 3 | 4 | | DET | May 28 01:10 PM EDT (Wed) | Comerica Park |
| May 30 | SF | | 2 | 0 |  | MIA | May 30 07:10 PM EDT (Fri) | loanDepot park |
| May 31 | SF | | 0 | 1 | | MIA | May 31 04:10 PM EDT (Sat) | loanDepot park |
