| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Sep 01 | LAA |  | 3 | 8 |  | HOU | Sep 01 02:10 PM EDT (Mon) | Daikin Park |
| Sep 02 | NYY |  | 7 | 1 | | HOU | Sep 02 08:10 PM EDT (Tue) | Daikin Park |
| Sep 03 | NYY | | 7 | 8 | | HOU | Sep 03 08:10 PM EDT (Wed) | Daikin Park |
| Sep 04 | NYY | | 8 | 4 | | HOU | Sep 04 07:40 PM EDT (Thu) | Daikin Park |
| Sep 05 | HOU | | 3 | 4 |  | TEX | Sep 05 08:05 PM EDT (Fri) | Globe Life Field |
| Sep 06 | HOU | | 11 | 0 | | TEX | Sep 06 07:15 PM EDT (Sat) | Globe Life Field |
| Sep 07 | HOU | | 2 | 4 | | TEX | Sep 07 02:35 PM EDT (Sun) | Globe Life Field |
| Sep 09 | HOU | | 3 | 4 |  | TOR | Sep 09 07:07 PM EDT (Tue) | Rogers Centre |
| Sep 10 | HOU | | 3 | 2 | | TOR | Sep 10 07:07 PM EDT (Wed) | Rogers Centre |
| Sep 11 | HOU | | 0 | 6 | | TOR | Sep 11 03:07 PM EDT (Thu) | Rogers Centre |
| Sep 12 | HOU | | 11 | 3 |  | ATL | Sep 12 07:15 PM EDT (Fri) | Truist Park |
| Sep 13 | HOU | | 6 | 2 | | ATL | Sep 13 07:15 PM EDT (Sat) | Truist Park |
| Sep 14 | HOU | | 3 | 8 | | ATL | Sep 14 01:35 PM EDT (Sun) | Truist Park |
| Sep 15 | TEX | | 3 | 6 | | HOU | Sep 15 08:10 PM EDT (Mon) | Daikin Park |
| Sep 16 | TEX | | 5 | 6 | | HOU | Sep 16 08:10 PM EDT (Tue) | Daikin Park |
| Sep 17 | TEX | | 2 | 5 | | HOU | Sep 17 08:10 PM EDT (Wed) | Daikin Park |
| Sep 19 | SEA |  | 4 | 0 | | HOU | Sep 19 08:10 PM EDT (Fri) | Daikin Park |
| Sep 20 | SEA | | 6 | 4 | | HOU | Sep 20 07:10 PM EDT (Sat) | Daikin Park |
| Sep 21 | SEA | | 7 | 3 | | HOU | Sep 21 07:10 PM EDT (Sun) | Daikin Park |
| Sep 23 | HOU | | 1 | 5 |  | LV | Sep 23 10:05 PM EDT (Tue) | Sutter Health Park |
| Sep 24 | HOU | | 0 | 6 | | LV | Sep 24 10:05 PM EDT (Wed) | Sutter Health Park |
| Sep 25 | HOU | | 11 | 5 | | LV | Sep 25 03:35 PM EDT (Thu) | Sutter Health Park |
| Sep 26 | HOU | | 3 | 4 | | LAA | Sep 26 09:38 PM EDT (Fri) | Angel Stadium |
| Sep 27 | HOU | | 6 | 1 | | LAA | Sep 27 09:38 PM EDT (Sat) | Angel Stadium |
| Sep 28 | HOU | | 6 | 2 | | LAA | Sep 28 03:07 PM EDT (Sun) | Angel Stadium |
