| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Sep 02 | LAD |  | 7 | 9 |  | PIT | Sep 02 06:40 PM EDT (Tue) | PNC Park |
| Sep 03 | LAD | | 0 | 3 | | PIT | Sep 03 06:40 PM EDT (Wed) | PNC Park |
| Sep 04 | LAD | | 3 | 5 | | PIT | Sep 04 06:40 PM EDT (Thu) | PNC Park |
| Sep 05 | MIL |  | 5 | 2 | | PIT | Sep 05 06:40 PM EDT (Fri) | PNC Park |
| Sep 06 | MIL | | 4 | 1 | | PIT | Sep 06 06:40 PM EDT (Sat) | PNC Park |
| Sep 07 | MIL | | 10 | 2 | | PIT | Sep 07 01:35 PM EDT (Sun) | PNC Park |
| Sep 09 | PIT | | 2 | 3 |  | BAL | Sep 09 06:35 PM EDT (Tue) | Oriole Park at Camden Yards |
| Sep 10 | PIT | | 1 | 2 | | BAL | Sep 10 06:35 PM EDT (Wed) | Oriole Park at Camden Yards |
| Sep 11 | PIT | | 2 | 3 | | BAL | Sep 11 01:05 PM EDT (Thu) | Oriole Park at Camden Yards |
| Sep 12 | PIT | | 5 | 6 |  | WAS | Sep 12 06:45 PM EDT (Fri) | Nationals Park |
| Sep 13 | PIT | | 5 | 1 | | WAS | Sep 13 04:05 PM EDT (Sat) | Nationals Park |
| Sep 14 | PIT | | 3 | 4 | | WAS | Sep 14 11:35 AM EDT (Sun) | Nationals Park |
| Sep 15 | CHC |  | 4 | 0 | | PIT | Sep 15 06:40 PM EDT (Mon) | PNC Park |
| Sep 16 | CHC | | 4 | 1 | | PIT | Sep 16 06:40 PM EDT (Tue) | PNC Park |
| Sep 17 | CHC | | 8 | 4 | | PIT | Sep 17 12:35 PM EDT (Wed) | PNC Park |
| Sep 19 | LV |  | 4 | 3 | | PIT | Sep 19 06:40 PM EDT (Fri) | PNC Park |
| Sep 20 | LV | | 0 | 2 | | PIT | Sep 20 06:40 PM EDT (Sat) | PNC Park |
| Sep 21 | LV | | 0 | 11 | | PIT | Sep 21 01:35 PM EDT (Sun) | PNC Park |
| Sep 23 | PIT | | 4 | 2 |  | CIN | Sep 23 06:40 PM EDT (Tue) | Great American Ball Park |
| Sep 24 | PIT | | 4 | 3 | | CIN | Sep 24 06:40 PM EDT (Wed) | Great American Ball Park |
| Sep 25 | PIT | | 1 | 2 | | CIN | Sep 25 12:40 PM EDT (Thu) | Great American Ball Park |
| Sep 26 | PIT | | 9 | 3 |  | ATL | Sep 26 07:15 PM EDT (Fri) | Truist Park |
| Sep 27 | PIT | | 3 | 1 | | ATL | Sep 27 07:15 PM EDT (Sat) | Truist Park |
| Sep 28 | PIT | | 1 | 4 | | ATL | Sep 28 03:15 PM EDT (Sun) | Truist Park |
