| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Sep 01 | SEA |  | 2 | 10 |  | TB | Sep 01 07:35 PM EDT (Mon) | George M. Steinbrenner Field |
| Sep 02 | SEA | | 5 | 6 | | TB | Sep 02 07:35 PM EDT (Tue) | George M. Steinbrenner Field |
| Sep 03 | SEA | | 4 | 9 | | TB | Sep 03 07:35 PM EDT (Wed) | George M. Steinbrenner Field |
| Sep 05 | SEA | | 1 | 4 |  | ATL | Sep 05 07:15 PM EDT (Fri) | Truist Park |
| Sep 06 | SEA | | 10 | 2 | | ATL | Sep 06 07:15 PM EDT (Sat) | Truist Park |
| Sep 07 | SEA | | 18 | 2 | | ATL | Sep 07 12:05 PM EDT (Sun) | Truist Park |
| Sep 08 | STL |  | 2 | 4 | | SEA | Sep 08 09:40 PM EDT (Mon) | T-Mobile Park |
| Sep 09 | STL | | 3 | 5 | | SEA | Sep 09 09:40 PM EDT (Tue) | T-Mobile Park |
| Sep 10 | STL | | 2 | 4 | | SEA | Sep 10 09:40 PM EDT (Wed) | T-Mobile Park |
| Sep 11 | LAA |  | 6 | 7 | | SEA | Sep 11 09:40 PM EDT (Thu) | T-Mobile Park |
| Sep 12 | LAA | | 1 | 2 | | SEA | Sep 12 10:10 PM EDT (Fri) | T-Mobile Park |
| Sep 13 | LAA | | 3 | 5 | | SEA | Sep 13 09:40 PM EDT (Sat) | T-Mobile Park |
| Sep 14 | LAA | | 2 | 11 | | SEA | Sep 14 04:10 PM EDT (Sun) | T-Mobile Park |
| Sep 16 | SEA | | 12 | 5 |  | KC | Sep 16 07:40 PM EDT (Tue) | Kauffman Stadium |
| Sep 17 | SEA | | 5 | 7 | | KC | Sep 17 07:40 PM EDT (Wed) | Kauffman Stadium |
| Sep 18 | SEA | | 2 | 0 | | KC | Sep 18 02:10 PM EDT (Thu) | Kauffman Stadium |
| Sep 19 | SEA | | 4 | 0 |  | HOU | Sep 19 08:10 PM EDT (Fri) | Daikin Park |
| Sep 20 | SEA | | 6 | 4 | | HOU | Sep 20 07:10 PM EDT (Sat) | Daikin Park |
| Sep 21 | SEA | | 7 | 3 | | HOU | Sep 21 07:10 PM EDT (Sun) | Daikin Park |
| Sep 23 | COL |  | 3 | 4 | | SEA | Sep 23 09:40 PM EDT (Tue) | T-Mobile Park |
| Sep 24 | COL | | 2 | 9 | | SEA | Sep 24 09:40 PM EDT (Wed) | T-Mobile Park |
| Sep 25 | COL | | 2 | 6 | | SEA | Sep 25 09:40 PM EDT (Thu) | T-Mobile Park |
| Sep 26 | LAD |  | 3 | 2 | | SEA | Sep 26 09:40 PM EDT (Fri) | T-Mobile Park |
| Sep 27 | LAD | | 5 | 3 | | SEA | Sep 27 09:40 PM EDT (Sat) | T-Mobile Park |
| Sep 28 | LAD | | 6 | 1 | | SEA | Sep 28 03:10 PM EDT (Sun) | T-Mobile Park |
