| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Sep 01 | SF |  | 8 | 2 |  | COL | Sep 01 04:10 PM EDT (Mon) | Coors Field |
| Sep 02 | SF | | 7 | 4 | | COL | Sep 02 08:40 PM EDT (Tue) | Coors Field |
| Sep 03 | SF | | 10 | 8 | | COL | Sep 03 08:40 PM EDT (Wed) | Coors Field |
| Sep 05 | SF | | 8 | 2 |  | STL | Sep 05 08:15 PM EDT (Fri) | Busch Stadium |
| Sep 06 | SF | | 2 | 3 | | STL | Sep 06 07:15 PM EDT (Sat) | Busch Stadium |
| Sep 07 | SF | | 3 | 4 | | STL | Sep 07 02:15 PM EDT (Sun) | Busch Stadium |
| Sep 08 | ARI |  | 5 | 11 | | SF | Sep 08 09:45 PM EDT (Mon) | Oracle Park |
| Sep 09 | ARI | | 3 | 5 | | SF | Sep 09 09:45 PM EDT (Tue) | Oracle Park |
| Sep 10 | ARI | | 5 | 3 | | SF | Sep 10 03:45 PM EDT (Wed) | Oracle Park |
| Sep 12 | LAD |  | 1 | 5 | | SF | Sep 12 10:15 PM EDT (Fri) | Oracle Park |
| Sep 13 | LAD | | 13 | 7 | | SF | Sep 13 09:05 PM EDT (Sat) | Oracle Park |
| Sep 14 | LAD | | 10 | 2 | | SF | Sep 14 04:05 PM EDT (Sun) | Oracle Park |
| Sep 15 | SF | | 1 | 8 | | ARI | Sep 15 09:40 PM EDT (Mon) | Chase Field |
| Sep 16 | SF | | 5 | 6 | | ARI | Sep 16 09:40 PM EDT (Tue) | Chase Field |
| Sep 17 | SF | | 5 | 1 | | ARI | Sep 17 03:40 PM EDT (Wed) | Chase Field |
| Sep 18 | SF | | 1 | 2 | | LAD | Sep 18 10:10 PM EDT (Thu) | Dodger Stadium |
| Sep 19 | SF | | 3 | 6 | | LAD | Sep 19 10:10 PM EDT (Fri) | Dodger Stadium |
| Sep 20 | SF | | 5 | 7 | | LAD | Sep 20 09:10 PM EDT (Sat) | Dodger Stadium |
| Sep 21 | SF | | 3 | 1 | | LAD | Sep 21 04:10 PM EDT (Sun) | Dodger Stadium |
| Sep 22 | STL | | 6 | 5 | | SF | Sep 22 09:45 PM EDT (Mon) | Oracle Park |
| Sep 23 | STL | | 9 | 8 | | SF | Sep 23 09:45 PM EDT (Tue) | Oracle Park |
| Sep 24 | STL | | 3 | 4 | | SF | Sep 24 09:45 PM EDT (Wed) | Oracle Park |
| Sep 26 | COL | | 3 | 6 | | SF | Sep 26 10:15 PM EDT (Fri) | Oracle Park |
| Sep 27 | COL | | 3 | 4 | | SF | Sep 27 04:05 PM EDT (Sat) | Oracle Park |
| Sep 28 | COL | | 0 | 4 | | SF | Sep 28 03:05 PM EDT (Sun) | Oracle Park |
