| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 02 | BOS |  | 3 | 0 |  | BAL | Apr 02 06:35 PM EDT (Wed) | Oriole Park at Camden Yards |
| Apr 03 | BOS | | 8 | 4 | | BAL | Apr 03 01:05 PM EDT (Thu) | Oriole Park at Camden Yards |
| Apr 04 | STL |  | 9 | 13 | | BOS | Apr 04 02:10 PM EDT (Fri) | Fenway Park |
| Apr 05 | STL | | (postponed) | | BOS | Apr 05 04:10 PM EDT (Sat) | Fenway Park (resch Apr 06) |
| Apr 06 | STL | | 4 | 5 | | BOS | Apr 06 01:35 PM EDT (Sun) | Fenway Park |
| Apr 06 | STL | | 7 | 18 | | BOS | Apr 06 07:10 PM EDT (Sun) | Fenway Park |
| Apr 07 | TOR |  | 6 | 2 | | BOS | Apr 07 06:45 PM EDT (Mon) | Fenway Park |
| Apr 08 | TOR | | 6 | 1 | | BOS | Apr 08 06:45 PM EDT (Tue) | Fenway Park |
| Apr 09 | TOR | | 2 | 1 | | BOS | Apr 09 06:45 PM EDT (Wed) | Fenway Park |
| Apr 10 | TOR | | 3 | 4 | | BOS | Apr 10 04:10 PM EDT (Thu) | Fenway Park |
| Apr 11 | BOS | | 1 | 11 |  | CHW | Apr 11 07:40 PM EDT (Fri) | Rate Field |
| Apr 12 | BOS | | 2 | 3 | | CHW | Apr 12 04:10 PM EDT (Sat) | Rate Field |
| Apr 13 | BOS | | 3 | 1 | | CHW | Apr 13 02:10 PM EDT (Sun) | Rate Field |
| Apr 14 | BOS | | 1 | 16 |  | TB | Apr 14 07:05 PM EDT (Mon) | George M. Steinbrenner Field |
| Apr 15 | BOS | | 7 | 4 | | TB | Apr 15 07:05 PM EDT (Tue) | George M. Steinbrenner Field |
| Apr 16 | BOS | | 1 | 0 | | TB | Apr 16 07:05 PM EDT (Wed) | George M. Steinbrenner Field |
| Apr 18 | CHW | | 3 | 10 | | BOS | Apr 18 07:10 PM EDT (Fri) | Fenway Park |
| Apr 19 | CHW | | 3 | 4 | | BOS | Apr 19 04:10 PM EDT (Sat) | Fenway Park |
| Apr 20 | CHW | | 8 | 4 | | BOS | Apr 20 01:35 PM EDT (Sun) | Fenway Park |
| Apr 21 | CHW | | 2 | 4 | | BOS | Apr 21 11:10 AM EDT (Mon) | Fenway Park |
| Apr 22 | SEA |  | 3 | 8 | | BOS | Apr 22 06:45 PM EDT (Tue) | Fenway Park |
| Apr 23 | SEA | | 8 | 5 | | BOS | Apr 23 06:45 PM EDT (Wed) | Fenway Park |
| Apr 24 | SEA | | 4 | 3 | | BOS | Apr 24 01:35 PM EDT (Thu) | Fenway Park |
| Apr 25 | BOS | | (postponed) |  | CLE | Apr 25 01:10 PM EDT (Fri) | Progressive Field (resch Apr 26) |
| Apr 26 | BOS | | 4 | 5 | | CLE | Apr 26 01:10 PM EDT (Sat) | Progressive Field |
| Apr 26 | BOS | | 7 | 3 | | CLE | Apr 26 06:10 PM EDT (Sat) | Progressive Field |
| Apr 27 | BOS | | 13 | 3 | | CLE | Apr 27 01:40 PM EDT (Sun) | Progressive Field |
| Apr 29 | BOS | | 10 | 2 | | TOR | Apr 29 07:07 PM EDT (Tue) | Rogers Centre |
| Apr 30 | BOS | | 6 | 7 | | TOR | Apr 30 07:07 PM EDT (Wed) | Rogers Centre |
