| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Mar 27 | BOS |  | 5 | 2 |  | TEX | Mar 27 04:05 PM EDT (Thu) | Globe Life Field |
| Mar 28 | BOS | | 1 | 4 | | TEX | Mar 28 08:05 PM EDT (Fri) | Globe Life Field |
| Mar 29 | BOS | | 3 | 4 | | TEX | Mar 29 07:05 PM EDT (Sat) | Globe Life Field |
| Mar 30 | BOS | | 2 | 3 | | TEX | Mar 30 02:35 PM EDT (Sun) | Globe Life Field |
| Mar 31 | BOS | | 5 | 8 |  | BAL | Mar 31 02:35 PM EDT (Mon) | Oriole Park at Camden Yards |
| Apr 02 | BOS | | 3 | 0 | | BAL | Apr 02 06:35 PM EDT (Wed) | Oriole Park at Camden Yards |
| Apr 03 | BOS | | 8 | 4 | | BAL | Apr 03 01:05 PM EDT (Thu) | Oriole Park at Camden Yards |
| Apr 04 | STL |  | 9 | 13 | | BOS | Apr 04 02:10 PM EDT (Fri) | Fenway Park |
| Apr 05 | STL | | (postponed) | | BOS | Apr 05 04:10 PM EDT (Sat) | Fenway Park (resch Apr 06) |
| Apr 06 | STL | | 4 | 5 | | BOS | Apr 06 01:35 PM EDT (Sun) | Fenway Park |
| Apr 06 | STL | | 7 | 18 | | BOS | Apr 06 07:10 PM EDT (Sun) | Fenway Park |
| Apr 07 | TOR |  | 6 | 2 | | BOS | Apr 07 06:45 PM EDT (Mon) | Fenway Park |
| Apr 08 | TOR | | 6 | 1 | | BOS | Apr 08 06:45 PM EDT (Tue) | Fenway Park |
| Apr 09 | TOR | | 2 | 1 | | BOS | Apr 09 06:45 PM EDT (Wed) | Fenway Park |
| Apr 10 | TOR | | 3 | 4 | | BOS | Apr 10 04:10 PM EDT (Thu) | Fenway Park |
| Apr 11 | BOS | | 1 | 11 |  | CHW | Apr 11 07:40 PM EDT (Fri) | Rate Field |
| Apr 12 | BOS | | 2 | 3 | | CHW | Apr 12 04:10 PM EDT (Sat) | Rate Field |
| Apr 13 | BOS | | 3 | 1 | | CHW | Apr 13 02:10 PM EDT (Sun) | Rate Field |
| Apr 14 | BOS | | 1 | 16 |  | TB | Apr 14 07:05 PM EDT (Mon) | George M. Steinbrenner Field |
| Apr 15 | BOS | | 7 | 4 | | TB | Apr 15 07:05 PM EDT (Tue) | George M. Steinbrenner Field |
| Apr 16 | BOS | | 1 | 0 | | TB | Apr 16 07:05 PM EDT (Wed) | George M. Steinbrenner Field |
| Apr 18 | CHW | | 3 | 10 | | BOS | Apr 18 07:10 PM EDT (Fri) | Fenway Park |
| Apr 19 | CHW | | 3 | 4 | | BOS | Apr 19 04:10 PM EDT (Sat) | Fenway Park |
| Apr 20 | CHW | | 8 | 4 | | BOS | Apr 20 01:35 PM EDT (Sun) | Fenway Park |
| Apr 21 | CHW | | 2 | 4 | | BOS | Apr 21 11:10 AM EDT (Mon) | Fenway Park |
| Apr 22 | SEA |  | 3 | 8 | | BOS | Apr 22 06:45 PM EDT (Tue) | Fenway Park |
| Apr 23 | SEA | | 8 | 5 | | BOS | Apr 23 06:45 PM EDT (Wed) | Fenway Park |
| Apr 24 | SEA | | 4 | 3 | | BOS | Apr 24 01:35 PM EDT (Thu) | Fenway Park |
| Apr 25 | BOS | | (postponed) |  | CLE | Apr 25 01:10 PM EDT (Fri) | Progressive Field (resch Apr 26) |
| Apr 26 | BOS | | 4 | 5 | | CLE | Apr 26 01:10 PM EDT (Sat) | Progressive Field |
| Apr 26 | BOS | | 7 | 3 | | CLE | Apr 26 06:10 PM EDT (Sat) | Progressive Field |
| Apr 27 | BOS | | 13 | 3 | | CLE | Apr 27 01:40 PM EDT (Sun) | Progressive Field |
| Apr 29 | BOS | | 10 | 2 | | TOR | Apr 29 07:07 PM EDT (Tue) | Rogers Centre |
| Apr 30 | BOS | | 6 | 7 | | TOR | Apr 30 07:07 PM EDT (Wed) | Rogers Centre |
| May 01 | BOS | | 2 | 4 | | TOR | May 01 07:07 PM EDT (Thu) | Rogers Centre |
| May 02 | MIN |  | 1 | 6 | | BOS | May 02 07:10 PM EDT (Fri) | Fenway Park |
| May 03 | MIN | | 4 | 3 | | BOS | May 03 04:10 PM EDT (Sat) | Fenway Park |
| May 04 | MIN | | 5 | 4 | | BOS | May 04 01:35 PM EDT (Sun) | Fenway Park |
| May 06 | TEX | | 6 | 1 | | BOS | May 06 06:45 PM EDT (Tue) | Fenway Park |
| May 07 | TEX | | 4 | 6 | | BOS | May 07 06:45 PM EDT (Wed) | Fenway Park |
| May 08 | TEX | | 0 | 5 | | BOS | May 08 01:35 PM EDT (Thu) | Fenway Park |
| May 09 | BOS | | 1 | 2 |  | KC | May 09 07:40 PM EDT (Fri) | Kauffman Stadium |
| May 10 | BOS | | 10 | 1 | | KC | May 10 07:10 PM EDT (Sat) | Kauffman Stadium |
| May 11 | BOS | | 3 | 1 | | KC | May 11 02:10 PM EDT (Sun) | Kauffman Stadium |
| May 12 | BOS | | 2 | 14 |  | DET | May 12 06:40 PM EDT (Mon) | Comerica Park |
| May 13 | BOS | | 9 | 10 | | DET | May 13 06:40 PM EDT (Tue) | Comerica Park |
| May 14 | BOS | | 5 | 6 | | DET | May 14 06:40 PM EDT (Wed) | Comerica Park |
| May 16 | ATL |  | 4 | 2 | | BOS | May 16 07:10 PM EDT (Fri) | Fenway Park |
| May 17 | ATL | | 6 | 7 | | BOS | May 17 07:15 PM EDT (Sat) | Fenway Park |
| May 18 | ATL | | 10 | 4 | | BOS | May 18 01:35 PM EDT (Sun) | Fenway Park |
| May 19 | NYM |  | 1 | 3 | | BOS | May 19 06:45 PM EDT (Mon) | Fenway Park |
| May 20 | NYM | | 0 | 2 | | BOS | May 20 06:45 PM EDT (Tue) | Fenway Park |
| May 21 | NYM | | 5 | 1 | | BOS | May 21 06:45 PM EDT (Wed) | Fenway Park |
| May 22 | BAL | | (postponed) | | BOS | May 22 06:45 PM EDT (Thu) | Fenway Park (resch May 23) |
| May 23 | BAL | | 5 | 19 | | BOS | May 23 01:35 PM EDT (Fri) | Fenway Park |
| May 23 | BAL | | (postponed) | | BOS | May 23 07:10 PM EDT (Fri) | Fenway Park (resch May 24) |
| May 24 | BAL | | 5 | 6 | | BOS | May 24 01:05 PM EDT (Sat) | Fenway Park |
| May 24 | BAL | | 2 | 1 | | BOS | May 24 06:35 PM EDT (Sat) | Fenway Park |
| May 25 | BAL | | 5 | 1 | | BOS | May 25 01:35 PM EDT (Sun) | Fenway Park |
| May 26 | BOS | | 2 | 3 |  | MIL | May 26 02:10 PM EDT (Mon) | American Family Field |
| May 27 | BOS | | 1 | 5 | | MIL | May 27 07:40 PM EDT (Tue) | American Family Field |
| May 28 | BOS | | 5 | 6 | | MIL | May 28 01:10 PM EDT (Wed) | American Family Field |
| May 30 | BOS | | 5 | 1 | | ATL | May 30 07:15 PM EDT (Fri) | Truist Park |
| May 31 | BOS | | 0 | 5 | | ATL | May 31 04:10 PM EDT (Sat) | Truist Park |
| Jun 01 | BOS | | 3 | 1 | | ATL | Jun 01 01:35 PM EDT (Sun) | Truist Park |
| Jun 02 | LAA |  | 7 | 6 | | BOS | Jun 02 07:10 PM EDT (Mon) | Fenway Park |
| Jun 03 | LAA | | 4 | 3 | | BOS | Jun 03 07:10 PM EDT (Tue) | Fenway Park |
| Jun 04 | LAA | | 9 | 11 | | BOS | Jun 04 01:35 PM EDT (Wed) | Fenway Park |
| Jun 06 | BOS | | 6 | 9 |  | NYY | Jun 06 07:05 PM EDT (Fri) | Yankee Stadium |
| Jun 07 | BOS | | 10 | 7 | | NYY | Jun 07 07:35 PM EDT (Sat) | Yankee Stadium |
| Jun 08 | BOS | | 11 | 7 | | NYY | Jun 08 07:10 PM EDT (Sun) | Yankee Stadium |
| Jun 09 | TB | | 10 | 8 | | BOS | Jun 09 07:10 PM EDT (Mon) | Fenway Park |
| Jun 10 | TB | | 1 | 3 | | BOS | Jun 10 07:10 PM EDT (Tue) | Fenway Park |
| Jun 11 | TB | | 3 | 4 | | BOS | Jun 11 07:10 PM EDT (Wed) | Fenway Park |
| Jun 13 | NYY | | 1 | 2 | | BOS | Jun 13 07:10 PM EDT (Fri) | Fenway Park |
| Jun 14 | NYY | | 3 | 4 | | BOS | Jun 14 07:15 PM EDT (Sat) | Fenway Park |
| Jun 15 | NYY | | 0 | 2 | | BOS | Jun 15 01:35 PM EDT (Sun) | Fenway Park |
| Jun 16 | BOS | | 2 | 0 | | SEA | Jun 16 09:40 PM EDT (Mon) | T-Mobile Park |
| Jun 17 | BOS | | 0 | 8 | | SEA | Jun 17 09:40 PM EDT (Tue) | T-Mobile Park |
| Jun 18 | BOS | | 3 | 1 | | SEA | Jun 18 04:10 PM EDT (Wed) | T-Mobile Park |
| Jun 20 | BOS | | 7 | 5 |  | SF | Jun 20 10:15 PM EDT (Fri) | Oracle Park |
| Jun 21 | BOS | | 2 | 3 | | SF | Jun 21 04:05 PM EDT (Sat) | Oracle Park |
| Jun 22 | BOS | | 5 | 9 | | SF | Jun 22 04:05 PM EDT (Sun) | Oracle Park |
| Jun 23 | BOS | | 5 | 9 | | LAA | Jun 23 09:38 PM EDT (Mon) | Angel Stadium |
| Jun 24 | BOS | | 2 | 3 | | LAA | Jun 24 09:38 PM EDT (Tue) | Angel Stadium |
| Jun 25 | BOS | | 2 | 5 | | LAA | Jun 25 04:07 PM EDT (Wed) | Angel Stadium |
| Jun 27 | TOR | | 9 | 0 | | BOS | Jun 27 07:10 PM EDT (Fri) | Fenway Park |
| Jun 28 | TOR | | 1 | 15 | | BOS | Jun 28 04:10 PM EDT (Sat) | Fenway Park |
| Jun 29 | TOR | | 5 | 3 | | BOS | Jun 29 01:35 PM EDT (Sun) | Fenway Park |
| Jun 30 | CIN |  | 6 | 13 | | BOS | Jun 30 07:10 PM EDT (Mon) | Fenway Park |
