| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Mar 27 | MIN |  | 3 | 5 |  | STL | Mar 27 04:15 PM EDT (Thu) | Busch Stadium |
| Mar 29 | MIN | | 1 | 5 | | STL | Mar 29 02:15 PM EDT (Sat) | Busch Stadium |
| Mar 30 | MIN | | 2 | 9 | | STL | Mar 30 02:15 PM EDT (Sun) | Busch Stadium |
| Mar 31 | LAA |  | 5 | 4 | | STL | Mar 31 07:45 PM EDT (Mon) | Busch Stadium |
| Apr 01 | LAA | | 9 | 7 | | STL | Apr 01 07:45 PM EDT (Tue) | Busch Stadium |
| Apr 02 | LAA | | 5 | 12 | | STL | Apr 02 01:15 PM EDT (Wed) | Busch Stadium |
| Apr 04 | STL | | 9 | 13 |  | BOS | Apr 04 02:10 PM EDT (Fri) | Fenway Park |
| Apr 05 | STL | | (postponed) | | BOS | Apr 05 04:10 PM EDT (Sat) | Fenway Park (resch Apr 06) |
| Apr 06 | STL | | 4 | 5 | | BOS | Apr 06 01:35 PM EDT (Sun) | Fenway Park |
| Apr 06 | STL | | 7 | 18 | | BOS | Apr 06 07:10 PM EDT (Sun) | Fenway Park |
| Apr 07 | STL | | 4 | 8 |  | PIT | Apr 07 06:40 PM EDT (Mon) | PNC Park |
| Apr 08 | STL | | 5 | 3 | | PIT | Apr 08 06:40 PM EDT (Tue) | PNC Park |
| Apr 09 | STL | | 1 | 2 | | PIT | Apr 09 12:35 PM EDT (Wed) | PNC Park |
| Apr 11 | PHI |  | 0 | 2 | | STL | Apr 11 08:15 PM EDT (Fri) | Busch Stadium |
| Apr 12 | PHI | | 4 | 1 | | STL | Apr 12 02:15 PM EDT (Sat) | Busch Stadium |
| Apr 13 | PHI | | 0 | 7 | | STL | Apr 13 02:15 PM EDT (Sun) | Busch Stadium |
| Apr 14 | HOU |  | 3 | 8 | | STL | Apr 14 07:45 PM EDT (Mon) | Busch Stadium |
| Apr 15 | HOU | | 2 | 0 | | STL | Apr 15 07:45 PM EDT (Tue) | Busch Stadium |
| Apr 16 | HOU | | 1 | 4 | | STL | Apr 16 01:15 PM EDT (Wed) | Busch Stadium |
| Apr 17 | STL | | 1 | 4 |  | NYM | Apr 17 07:10 PM EDT (Thu) | Citi Field |
| Apr 18 | STL | | 4 | 5 | | NYM | Apr 18 07:10 PM EDT (Fri) | Citi Field |
| Apr 19 | STL | | 0 | 3 | | NYM | Apr 19 04:05 PM EDT (Sat) | Citi Field |
| Apr 20 | STL | | 4 | 7 | | NYM | Apr 20 01:40 PM EDT (Sun) | Citi Field |
| Apr 21 | STL | | 6 | 7 |  | ATL | Apr 21 07:15 PM EDT (Mon) | Truist Park |
| Apr 22 | STL | | 10 | 4 | | ATL | Apr 22 07:15 PM EDT (Tue) | Truist Park |
| Apr 23 | STL | | 1 | 4 | | ATL | Apr 23 12:15 PM EDT (Wed) | Truist Park |
| Apr 25 | MIL |  | 2 | 3 | | STL | Apr 25 08:15 PM EDT (Fri) | Busch Stadium |
| Apr 26 | MIL | | 5 | 6 | | STL | Apr 26 02:15 PM EDT (Sat) | Busch Stadium |
| Apr 27 | MIL | | 7 | 1 | | STL | Apr 27 02:15 PM EDT (Sun) | Busch Stadium |
| Apr 28 | STL | | 1 | 3 |  | CIN | Apr 28 06:40 PM EDT (Mon) | Great American Ball Park |
| Apr 29 | STL | | (postponed) | | CIN | Apr 29 12:40 PM EDT (Tue) | Great American Ball Park (resch Apr 30) |
| Apr 30 | STL | | 6 | 0 | | CIN | Apr 30 12:40 PM EDT (Wed) | Great American Ball Park |
| Apr 30 | STL | | 9 | 1 | | CIN | Apr 30 06:40 PM EDT (Wed) | Great American Ball Park |
| May 01 | STL | | 1 | 9 | | CIN | May 01 12:40 PM EDT (Thu) | Great American Ball Park |
| May 02 | NYM | | 9 | 3 | | STL | May 02 08:15 PM EDT (Fri) | Busch Stadium |
| May 03 | NYM | | (postponed) | | STL | May 03 02:15 PM EDT (Sat) | Busch Stadium (resch May 04) |
| May 04 | NYM | | 5 | 6 | | STL | May 04 01:15 PM EDT (Sun) | Busch Stadium |
| May 04 | NYM | | 4 | 5 | | STL | May 04 06:15 PM EDT (Sun) | Busch Stadium |
| May 05 | PIT | | 3 | 6 | | STL | May 05 07:45 PM EDT (Mon) | Busch Stadium |
| May 06 | PIT | | 1 | 2 | | STL | May 06 07:45 PM EDT (Tue) | Busch Stadium |
| May 07 | PIT | | 0 | 5 | | STL | May 07 01:15 PM EDT (Wed) | Busch Stadium |
| May 09 | STL | | 10 | 0 |  | WAS | May 09 06:45 PM EDT (Fri) | Nationals Park |
| May 10 | STL | | 4 | 2 | | WAS | May 10 04:05 PM EDT (Sat) | Nationals Park |
| May 11 | STL | | 6 | 1 | | WAS | May 11 01:35 PM EDT (Sun) | Nationals Park |
| May 12 | STL | | 3 | 2 | | PHI | May 12 06:45 PM EDT (Mon) | Citizens Bank Park |
| May 13 | STL | | (postponed) | | PHI | May 13 06:45 PM EDT (Tue) | Citizens Bank Park (resch May 14) |
| May 14 | STL | | 1 | 2 | | PHI | May 14 01:05 PM EDT (Wed) | Citizens Bank Park |
| May 14 | STL | | 14 | 7 | | PHI | May 14 06:15 PM EDT (Wed) | Citizens Bank Park |
| May 16 | STL | | 10 | 3 |  | KC | May 16 07:40 PM EDT (Fri) | Kauffman Stadium |
| May 17 | STL | | 1 | 0 | | KC | May 17 07:10 PM EDT (Sat) | Kauffman Stadium |
| May 18 | STL | | 1 | 2 | | KC | May 18 02:10 PM EDT (Sun) | Kauffman Stadium |
| May 19 | DET |  | 4 | 11 | | STL | May 19 07:45 PM EDT (Mon) | Busch Stadium |
| May 20 | DET | | 5 | 4 | | STL | May 20 07:45 PM EDT (Tue) | Busch Stadium |
| May 21 | DET | | 5 | 1 | | STL | May 21 01:15 PM EDT (Wed) | Busch Stadium |
| May 23 | ARI |  | 3 | 4 | | STL | May 23 08:15 PM EDT (Fri) | Busch Stadium |
| May 24 | ARI | | 5 | 6 | | STL | May 24 02:15 PM EDT (Sat) | Busch Stadium |
| May 25 | ARI | | 3 | 4 | | STL | May 25 02:15 PM EDT (Sun) | Busch Stadium |
| May 26 | STL | | 2 | 5 |  | BAL | May 26 03:05 PM EDT (Mon) | Oriole Park at Camden Yards |
| May 27 | STL | | 7 | 4 | | BAL | May 27 06:35 PM EDT (Tue) | Oriole Park at Camden Yards |
| May 28 | STL | | 6 | 4 | | BAL | May 28 06:35 PM EDT (Wed) | Oriole Park at Camden Yards |
| May 30 | STL | | 1 | 11 |  | TEX | May 30 08:05 PM EDT (Fri) | Globe Life Field |
| May 31 | STL | | 2 | 0 | | TEX | May 31 04:05 PM EDT (Sat) | Globe Life Field |
| Jun 01 | STL | | 1 | 8 | | TEX | Jun 01 01:05 PM EDT (Sun) | Globe Life Field |
| Jun 03 | KC | | 10 | 7 | | STL | Jun 03 07:45 PM EDT (Tue) | Busch Stadium |
| Jun 04 | KC | | (postponed) | | STL | Jun 04 01:45 PM EDT (Wed) | Busch Stadium (resch Jun 05) |
| Jun 05 | KC | | 5 | 6 | | STL | Jun 05 01:45 PM EDT (Thu) | Busch Stadium |
| Jun 05 | KC | | 7 | 5 | | STL | Jun 05 07:45 PM EDT (Thu) | Busch Stadium |
| Jun 06 | LAD |  | 0 | 5 | | STL | Jun 06 08:15 PM EDT (Fri) | Busch Stadium |
| Jun 07 | LAD | | 1 | 2 | | STL | Jun 07 02:15 PM EDT (Sat) | Busch Stadium |
| Jun 08 | LAD | | 7 | 3 | | STL | Jun 08 02:15 PM EDT (Sun) | Busch Stadium |
| Jun 09 | TOR |  | 5 | 4 | | STL | Jun 09 07:45 PM EDT (Mon) | Busch Stadium |
| Jun 10 | TOR | | 10 | 9 | | STL | Jun 10 07:45 PM EDT (Tue) | Busch Stadium |
| Jun 11 | TOR | | 5 | 2 | | STL | Jun 11 02:15 PM EDT (Wed) | Busch Stadium |
| Jun 12 | STL | | 0 | 6 | | MIL | Jun 12 07:40 PM EDT (Thu) | American Family Field |
| Jun 13 | STL | | 2 | 3 | | MIL | Jun 13 08:10 PM EDT (Fri) | American Family Field |
| Jun 14 | STL | | 8 | 5 | | MIL | Jun 14 04:10 PM EDT (Sat) | American Family Field |
| Jun 15 | STL | | 2 | 3 | | MIL | Jun 15 02:10 PM EDT (Sun) | American Family Field |
| Jun 17 | STL | | 12 | 2 |  | CHW | Jun 17 07:40 PM EDT (Tue) | Rate Field |
| Jun 18 | STL | | (postponed) | | CHW | Jun 18 07:40 PM EDT (Wed) | Rate Field (resch Jun 19) |
| Jun 19 | STL | | 5 | 4 | | CHW | Jun 19 02:10 PM EDT (Thu) | Rate Field |
| Jun 19 | STL | | 8 | 6 | | CHW | Jun 19 02:15 PM EDT (Thu) | Rate Field |
| Jun 20 | CIN | | 1 | 6 | | STL | Jun 20 07:15 PM EDT (Fri) | Busch Stadium |
| Jun 21 | CIN | | 5 | 6 | | STL | Jun 21 02:15 PM EDT (Sat) | Busch Stadium |
| Jun 22 | CIN | | 4 | 1 | | STL | Jun 22 02:15 PM EDT (Sun) | Busch Stadium |
| Jun 23 | CHC |  | 2 | 8 | | STL | Jun 23 07:45 PM EDT (Mon) | Busch Stadium |
| Jun 24 | CHC | | 7 | 8 | | STL | Jun 24 07:45 PM EDT (Tue) | Busch Stadium |
| Jun 25 | CHC | | 8 | 0 | | STL | Jun 25 07:45 PM EDT (Wed) | Busch Stadium |
| Jun 26 | CHC | | 3 | 0 | | STL | Jun 26 02:15 PM EDT (Thu) | Busch Stadium |
| Jun 27 | STL | | 5 | 0 |  | CLE | Jun 27 07:10 PM EDT (Fri) | Progressive Field |
| Jun 28 | STL | | 9 | 6 | | CLE | Jun 28 04:10 PM EDT (Sat) | Progressive Field |
| Jun 29 | STL | | 7 | 0 | | CLE | Jun 29 12:05 PM EDT (Sun) | Progressive Field |
| Jun 30 | STL | | 0 | 7 | | PIT | Jun 30 06:40 PM EDT (Mon) | PNC Park |
