| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Mar 27 | CLE |  | 7 | 4 |  | KC | Mar 27 04:10 PM EDT (Thu) | Kauffman Stadium |
| Mar 29 | CLE | | 3 | 4 | | KC | Mar 29 04:10 PM EDT (Sat) | Kauffman Stadium |
| Mar 30 | CLE | | 6 | 2 | | KC | Mar 30 02:10 PM EDT (Sun) | Kauffman Stadium |
| Mar 31 | CLE | | 2 | 7 |  | SD | Mar 31 09:40 PM EDT (Mon) | Petco Park |
| Apr 01 | CLE | | 0 | 7 | | SD | Apr 01 09:40 PM EDT (Tue) | Petco Park |
| Apr 02 | CLE | | 2 | 5 | | SD | Apr 02 04:10 PM EDT (Wed) | Petco Park |
| Apr 04 | CLE | | 8 | 6 |  | LAA | Apr 04 09:38 PM EDT (Fri) | Angel Stadium |
| Apr 05 | CLE | | 4 | 10 | | LAA | Apr 05 09:38 PM EDT (Sat) | Angel Stadium |
| Apr 06 | CLE | | 2 | 6 | | LAA | Apr 06 04:07 PM EDT (Sun) | Angel Stadium |
| Apr 08 | CHW |  | 0 | 1 | | CLE | Apr 08 04:10 PM EDT (Tue) | Progressive Field |
| Apr 09 | CHW | | 2 | 3 | | CLE | Apr 09 06:10 PM EDT (Wed) | Progressive Field |
| Apr 10 | CHW | | 1 | 6 | | CLE | Apr 10 01:10 PM EDT (Thu) | Progressive Field |
| Apr 11 | KC | | 0 | 7 | | CLE | Apr 11 06:10 PM EDT (Fri) | Progressive Field |
| Apr 12 | KC | | 3 | 6 | | CLE | Apr 12 06:10 PM EDT (Sat) | Progressive Field |
| Apr 13 | KC | | 4 | 2 | | CLE | Apr 13 01:40 PM EDT (Sun) | Progressive Field |
| Apr 15 | CLE | | 6 | 3 |  | BAL | Apr 15 07:05 PM EDT (Tue) | Oriole Park at Camden Yards |
| Apr 16 | CLE | | 1 | 9 | | BAL | Apr 16 06:35 PM EDT (Wed) | Oriole Park at Camden Yards |
| Apr 17 | CLE | | 2 | 6 | | BAL | Apr 17 06:35 PM EDT (Thu) | Oriole Park at Camden Yards |
| Apr 18 | CLE | | 10 | 7 |  | PIT | Apr 18 06:40 PM EDT (Fri) | PNC Park |
| Apr 19 | CLE | | 3 | 0 | | PIT | Apr 19 04:05 PM EDT (Sat) | PNC Park |
| Apr 20 | CLE | | 5 | 4 | | PIT | Apr 20 01:35 PM EDT (Sun) | PNC Park |
| Apr 21 | NYY |  | 4 | 6 | | CLE | Apr 21 06:10 PM EDT (Mon) | Progressive Field |
| Apr 22 | NYY | | 2 | 3 | | CLE | Apr 22 06:10 PM EDT (Tue) | Progressive Field |
| Apr 23 | NYY | | 5 | 1 | | CLE | Apr 23 01:10 PM EDT (Wed) | Progressive Field |
| Apr 25 | BOS |  | (postponed) | | CLE | Apr 25 01:10 PM EDT (Fri) | Progressive Field (resch Apr 26) |
| Apr 26 | BOS | | 4 | 5 | | CLE | Apr 26 01:10 PM EDT (Sat) | Progressive Field |
| Apr 26 | BOS | | 7 | 3 | | CLE | Apr 26 06:10 PM EDT (Sat) | Progressive Field |
| Apr 27 | BOS | | 13 | 3 | | CLE | Apr 27 01:40 PM EDT (Sun) | Progressive Field |
| Apr 28 | MIN |  | 11 | 1 | | CLE | Apr 28 06:10 PM EDT (Mon) | Progressive Field |
| Apr 29 | MIN | | 1 | 2 | | CLE | Apr 29 06:10 PM EDT (Tue) | Progressive Field |
| Apr 30 | MIN | | 2 | 4 | | CLE | Apr 30 06:10 PM EDT (Wed) | Progressive Field |
| May 01 | MIN | | 3 | 4 | | CLE | May 01 01:10 PM EDT (Thu) | Progressive Field |
| May 02 | CLE | | 3 | 5 |  | TOR | May 02 07:07 PM EDT (Fri) | Rogers Centre |
| May 03 | CLE | | 5 | 3 | | TOR | May 03 03:07 PM EDT (Sat) | Rogers Centre |
| May 04 | CLE | | 5 | 4 | | TOR | May 04 01:37 PM EDT (Sun) | Rogers Centre |
| May 05 | CLE | | (postponed) |  | WAS | May 05 06:45 PM EDT (Mon) | Nationals Park (resch May 06) |
| May 06 | CLE | | 9 | 10 | | WAS | May 06 03:35 PM EDT (Tue) | Nationals Park |
| May 06 | CLE | | 9 | 1 | | WAS | May 06 03:40 PM EDT (Tue) | Nationals Park |
| May 07 | CLE | | 8 | 6 | | WAS | May 07 12:05 PM EDT (Wed) | Nationals Park |
| May 09 | PHI |  | 0 | 6 | | CLE | May 09 07:10 PM EDT (Fri) | Progressive Field |
| May 10 | PHI | | 7 | 1 | | CLE | May 10 06:10 PM EDT (Sat) | Progressive Field |
| May 11 | PHI | | 3 | 0 | | CLE | May 11 07:10 PM EDT (Sun) | Progressive Field |
| May 12 | MIL |  | 0 | 5 | | CLE | May 12 06:10 PM EDT (Mon) | Progressive Field |
| May 13 | MIL | | 0 | 2 | | CLE | May 13 06:10 PM EDT (Tue) | Progressive Field |
| May 14 | MIL | | 9 | 5 | | CLE | May 14 01:10 PM EDT (Wed) | Progressive Field |
| May 16 | CLE | | 4 | 5 |  | CIN | May 16 05:10 PM EDT (Fri) | Great American Ball Park |
| May 17 | CLE | | 1 | 4 | | CIN | May 17 06:40 PM EDT (Sat) | Great American Ball Park |
| May 18 | CLE | | 1 | 3 | | CIN | May 18 01:40 PM EDT (Sun) | Great American Ball Park |
| May 19 | CLE | | 5 | 6 | | MIN | May 19 07:40 PM EDT (Mon) | Target Field |
| May 20 | CLE | | (postponed) | | MIN | May 20 07:40 PM EDT (Tue) | Target Field (resch Sep 20) |
| May 21 | CLE | | 5 | 1 | | MIN | May 21 03:55 PM EDT (Wed) | Target Field |
| May 22 | CLE | | 7 | 0 |  | DET | May 22 06:40 PM EDT (Thu) | Comerica Park |
| May 23 | CLE | | 3 | 1 | | DET | May 23 07:10 PM EDT (Fri) | Comerica Park |
| May 24 | CLE | | 7 | 5 | | DET | May 24 07:15 PM EDT (Sat) | Comerica Park |
| May 25 | CLE | | 0 | 5 | | DET | May 25 11:35 AM EDT (Sun) | Comerica Park |
| May 26 | LAD |  | 7 | 2 | | CLE | May 26 06:10 PM EDT (Mon) | Progressive Field |
| May 27 | LAD | | 9 | 5 | | CLE | May 27 06:10 PM EDT (Tue) | Progressive Field |
| May 28 | LAD | | 4 | 7 | | CLE | May 28 01:10 PM EDT (Wed) | Progressive Field |
| May 30 | LAA | | 4 | 1 | | CLE | May 30 07:10 PM EDT (Fri) | Progressive Field |
| May 31 | LAA | | 5 | 7 | | CLE | May 31 04:10 PM EDT (Sat) | Progressive Field |
| Jun 01 | LAA | | 2 | 4 | | CLE | Jun 01 01:40 PM EDT (Sun) | Progressive Field |
| Jun 03 | CLE | | 2 | 3 | | NYY | Jun 03 07:05 PM EDT (Tue) | Yankee Stadium |
| Jun 04 | CLE | | 4 | 0 | | NYY | Jun 04 07:05 PM EDT (Wed) | Yankee Stadium |
| Jun 05 | CLE | | 0 | 4 | | NYY | Jun 05 07:05 PM EDT (Thu) | Yankee Stadium |
| Jun 06 | HOU |  | 4 | 2 | | CLE | Jun 06 07:10 PM EDT (Fri) | Progressive Field |
| Jun 07 | HOU | | 5 | 3 | | CLE | Jun 07 04:10 PM EDT (Sat) | Progressive Field |
| Jun 08 | HOU | | 2 | 4 | | CLE | Jun 08 01:40 PM EDT (Sun) | Progressive Field |
| Jun 09 | CIN | | 7 | 4 | | CLE | Jun 09 06:40 PM EDT (Mon) | Progressive Field |
| Jun 10 | CIN | | 1 | 0 | | CLE | Jun 10 06:40 PM EDT (Tue) | Progressive Field |
| Jun 11 | CIN | | 2 | 11 | | CLE | Jun 11 01:10 PM EDT (Wed) | Progressive Field |
| Jun 13 | CLE | | 2 | 7 |  | SEA | Jun 13 10:10 PM EDT (Fri) | T-Mobile Park |
| Jun 14 | CLE | | 3 | 4 | | SEA | Jun 14 09:40 PM EDT (Sat) | T-Mobile Park |
| Jun 15 | CLE | | 0 | 6 | | SEA | Jun 15 04:10 PM EDT (Sun) | T-Mobile Park |
| Jun 17 | CLE | | 3 | 2 |  | SF | Jun 17 09:45 PM EDT (Tue) | Oracle Park |
| Jun 18 | CLE | | 4 | 2 | | SF | Jun 18 09:45 PM EDT (Wed) | Oracle Park |
| Jun 19 | CLE | | 1 | 2 | | SF | Jun 19 04:05 PM EDT (Thu) | Oracle Park |
| Jun 20 | CLE | | 1 | 5 |  | LV | Jun 20 10:05 PM EDT (Fri) | Sutter Health Park |
| Jun 21 | CLE | | 4 | 2 | | LV | Jun 21 10:05 PM EDT (Sat) | Sutter Health Park |
| Jun 22 | CLE | | 3 | 0 | | LV | Jun 22 04:05 PM EDT (Sun) | Sutter Health Park |
| Jun 24 | TOR | | 10 | 6 | | CLE | Jun 24 06:40 PM EDT (Tue) | Progressive Field |
| Jun 25 | TOR | | 4 | 5 | | CLE | Jun 25 06:40 PM EDT (Wed) | Progressive Field |
| Jun 26 | TOR | | 6 | 0 | | CLE | Jun 26 01:10 PM EDT (Thu) | Progressive Field |
| Jun 27 | STL |  | 5 | 0 | | CLE | Jun 27 07:10 PM EDT (Fri) | Progressive Field |
| Jun 28 | STL | | 9 | 6 | | CLE | Jun 28 04:10 PM EDT (Sat) | Progressive Field |
| Jun 29 | STL | | 7 | 0 | | CLE | Jun 29 12:05 PM EDT (Sun) | Progressive Field |
