| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Mar 27 | DET |  | 4 | 5 |  | LAD | Mar 27 07:10 PM EDT (Thu) | Dodger Stadium |
| Mar 28 | DET | | 5 | 8 | | LAD | Mar 28 10:10 PM EDT (Fri) | Dodger Stadium |
| Mar 29 | DET | | 3 | 7 | | LAD | Mar 29 09:10 PM EDT (Sat) | Dodger Stadium |
| Mar 31 | DET | | 9 | 6 |  | SEA | Mar 31 09:40 PM EDT (Mon) | T-Mobile Park |
| Apr 01 | DET | | 4 | 1 | | SEA | Apr 01 09:40 PM EDT (Tue) | T-Mobile Park |
| Apr 02 | DET | | 2 | 3 | | SEA | Apr 02 04:10 PM EDT (Wed) | T-Mobile Park |
| Apr 04 | CHW |  | 4 | 7 | | DET | Apr 04 01:10 PM EDT (Fri) | Comerica Park |
| Apr 05 | CHW | | 2 | 7 | | DET | Apr 05 01:10 PM EDT (Sat) | Comerica Park |
| Apr 06 | CHW | | 3 | 4 | | DET | Apr 06 01:40 PM EDT (Sun) | Comerica Park |
| Apr 07 | NYY |  | 2 | 6 | | DET | Apr 07 03:10 PM EDT (Mon) | Comerica Park |
| Apr 08 | NYY | | 0 | 5 | | DET | Apr 08 01:10 PM EDT (Tue) | Comerica Park |
| Apr 09 | NYY | | 4 | 3 | | DET | Apr 09 01:10 PM EDT (Wed) | Comerica Park |
| Apr 11 | DET | | 7 | 6 |  | MIN | Apr 11 08:10 PM EDT (Fri) | Target Field |
| Apr 12 | DET | | 4 | 0 | | MIN | Apr 12 02:10 PM EDT (Sat) | Target Field |
| Apr 13 | DET | | 1 | 5 | | MIN | Apr 13 02:10 PM EDT (Sun) | Target Field |
| Apr 14 | DET | | 9 | 1 |  | MIL | Apr 14 07:40 PM EDT (Mon) | American Family Field |
| Apr 15 | DET | | 0 | 5 | | MIL | Apr 15 07:40 PM EDT (Tue) | American Family Field |
| Apr 16 | DET | | 1 | 5 | | MIL | Apr 16 01:10 PM EDT (Wed) | American Family Field |
| Apr 17 | KC |  | 1 | 6 | | DET | Apr 17 06:40 PM EDT (Thu) | Comerica Park |
| Apr 18 | KC | | 3 | 7 | | DET | Apr 18 06:40 PM EDT (Fri) | Comerica Park |
| Apr 19 | KC | | 1 | 3 | | DET | Apr 19 01:10 PM EDT (Sat) | Comerica Park |
| Apr 20 | KC | | 4 | 3 | | DET | Apr 20 01:40 PM EDT (Sun) | Comerica Park |
| Apr 21 | SD |  | 4 | 6 | | DET | Apr 21 06:40 PM EDT (Mon) | Comerica Park |
| Apr 22 | SD | | 2 | 0 | | DET | Apr 22 06:40 PM EDT (Tue) | Comerica Park |
| Apr 23 | SD | | 0 | 6 | | DET | Apr 23 01:10 PM EDT (Wed) | Comerica Park |
| Apr 25 | BAL |  | (postponed) | | DET | Apr 25 06:10 PM EDT (Fri) | Comerica Park (resch Apr 26) |
| Apr 26 | BAL | | 3 | 4 | | DET | Apr 26 01:10 PM EDT (Sat) | Comerica Park |
| Apr 26 | BAL | | 2 | 6 | | DET | Apr 26 06:10 PM EDT (Sat) | Comerica Park |
| Apr 27 | BAL | | 0 | 7 | | DET | Apr 27 01:40 PM EDT (Sun) | Comerica Park |
| Apr 28 | DET | | 5 | 8 |  | HOU | Apr 28 08:10 PM EDT (Mon) | Daikin Park |
| Apr 29 | DET | | 4 | 6 | | HOU | Apr 29 08:10 PM EDT (Tue) | Daikin Park |
| Apr 30 | DET | | 7 | 4 | | HOU | Apr 30 02:10 PM EDT (Wed) | Daikin Park |
| May 01 | DET | | 10 | 4 |  | LAA | May 01 09:38 PM EDT (Thu) | Angel Stadium |
| May 02 | DET | | 9 | 1 | | LAA | May 02 09:38 PM EDT (Fri) | Angel Stadium |
| May 03 | DET | | 2 | 5 | | LAA | May 03 09:38 PM EDT (Sat) | Angel Stadium |
| May 04 | DET | | 13 | 1 | | LAA | May 04 04:07 PM EDT (Sun) | Angel Stadium |
| May 06 | DET | | (postponed) |  | COL | May 06 08:40 PM EDT (Tue) | Coors Field (resch May 08) |
| May 07 | DET | | 8 | 6 | | COL | May 07 08:40 PM EDT (Wed) | Coors Field |
| May 08 | DET | | 10 | 2 | | COL | May 08 03:10 PM EDT (Thu) | Coors Field |
| May 08 | DET | | 11 | 1 | | COL | May 08 03:15 PM EDT (Thu) | Coors Field |
| May 09 | TEX |  | 1 | 2 | | DET | May 09 06:40 PM EDT (Fri) | Comerica Park |
| May 10 | TEX | | 10 | 3 | | DET | May 10 06:10 PM EDT (Sat) | Comerica Park |
| May 11 | TEX | | 6 | 1 | | DET | May 11 01:40 PM EDT (Sun) | Comerica Park |
| May 12 | BOS |  | 2 | 14 | | DET | May 12 06:40 PM EDT (Mon) | Comerica Park |
| May 13 | BOS | | 9 | 10 | | DET | May 13 06:40 PM EDT (Tue) | Comerica Park |
| May 14 | BOS | | 5 | 6 | | DET | May 14 06:40 PM EDT (Wed) | Comerica Park |
| May 16 | DET | | 5 | 4 |  | TOR | May 16 07:07 PM EDT (Fri) | Rogers Centre |
| May 17 | DET | | 1 | 2 | | TOR | May 17 03:07 PM EDT (Sat) | Rogers Centre |
| May 18 | DET | | 3 | 2 | | TOR | May 18 01:37 PM EDT (Sun) | Rogers Centre |
| May 19 | DET | | 4 | 11 |  | STL | May 19 07:45 PM EDT (Mon) | Busch Stadium |
| May 20 | DET | | 5 | 4 | | STL | May 20 07:45 PM EDT (Tue) | Busch Stadium |
| May 21 | DET | | 5 | 1 | | STL | May 21 01:15 PM EDT (Wed) | Busch Stadium |
| May 22 | CLE |  | 7 | 0 | | DET | May 22 06:40 PM EDT (Thu) | Comerica Park |
| May 23 | CLE | | 3 | 1 | | DET | May 23 07:10 PM EDT (Fri) | Comerica Park |
| May 24 | CLE | | 7 | 5 | | DET | May 24 07:15 PM EDT (Sat) | Comerica Park |
| May 25 | CLE | | 0 | 5 | | DET | May 25 11:35 AM EDT (Sun) | Comerica Park |
| May 26 | SF |  | 1 | 3 | | DET | May 26 01:10 PM EDT (Mon) | Comerica Park |
| May 27 | SF | | 1 | 3 | | DET | May 27 06:40 PM EDT (Tue) | Comerica Park |
| May 28 | SF | | 3 | 4 | | DET | May 28 01:10 PM EDT (Wed) | Comerica Park |
| May 30 | DET | | 7 | 5 | | KC | May 30 08:10 PM EDT (Fri) | Kauffman Stadium |
| May 31 | DET | | 0 | 1 | | KC | May 31 04:10 PM EDT (Sat) | Kauffman Stadium |
| Jun 01 | DET | | 1 | 0 | | KC | Jun 01 02:10 PM EDT (Sun) | Kauffman Stadium |
| Jun 02 | DET | | 13 | 1 | | CHW | Jun 02 07:40 PM EDT (Mon) | Rate Field |
| Jun 03 | DET | | 1 | 8 | | CHW | Jun 03 07:40 PM EDT (Tue) | Rate Field |
| Jun 04 | DET | | 5 | 4 | | CHW | Jun 04 07:40 PM EDT (Wed) | Rate Field |
| Jun 05 | DET | | 2 | 3 | | CHW | Jun 05 02:10 PM EDT (Thu) | Rate Field |
| Jun 06 | CHC |  | 1 | 3 | | DET | Jun 06 07:10 PM EDT (Fri) | Comerica Park |
| Jun 07 | CHC | | 6 | 1 | | DET | Jun 07 01:10 PM EDT (Sat) | Comerica Park |
| Jun 08 | CHC | | 0 | 4 | | DET | Jun 08 01:40 PM EDT (Sun) | Comerica Park |
| Jun 10 | DET | | 5 | 3 | | BAL | Jun 10 06:35 PM EDT (Tue) | Oriole Park at Camden Yards |
| Jun 11 | DET | | 1 | 10 | | BAL | Jun 11 06:35 PM EDT (Wed) | Oriole Park at Camden Yards |
| Jun 12 | DET | | 4 | 1 | | BAL | Jun 12 06:35 PM EDT (Thu) | Oriole Park at Camden Yards |
| Jun 13 | CIN |  | 5 | 11 | | DET | Jun 13 07:10 PM EDT (Fri) | Comerica Park |
| Jun 14 | CIN | | 11 | 1 | | DET | Jun 14 01:10 PM EDT (Sat) | Comerica Park |
| Jun 15 | CIN | | 8 | 4 | | DET | Jun 15 12:05 PM EDT (Sun) | Comerica Park |
| Jun 17 | PIT |  | 3 | 7 | | DET | Jun 17 06:40 PM EDT (Tue) | Comerica Park |
| Jun 18 | PIT | | (postponed) | | DET | Jun 18 06:40 PM EDT (Wed) | Comerica Park (resch Jun 19) |
| Jun 19 | PIT | | 2 | 9 | | DET | Jun 19 01:10 PM EDT (Thu) | Comerica Park |
| Jun 19 | PIT | | 8 | 4 | | DET | Jun 19 06:10 PM EDT (Thu) | Comerica Park |
| Jun 20 | DET | | 8 | 14 |  | TB | Jun 20 07:05 PM EDT (Fri) | George M. Steinbrenner Field |
| Jun 21 | DET | | 3 | 8 | | TB | Jun 21 12:10 PM EDT (Sat) | George M. Steinbrenner Field |
| Jun 22 | DET | | 9 | 3 | | TB | Jun 22 12:10 PM EDT (Sun) | George M. Steinbrenner Field |
| Jun 24 | LV |  | 4 | 11 | | DET | Jun 24 06:40 PM EDT (Tue) | Comerica Park |
| Jun 25 | LV | | 3 | 0 | | DET | Jun 25 06:40 PM EDT (Wed) | Comerica Park |
| Jun 26 | LV | | 0 | 8 | | DET | Jun 26 01:10 PM EDT (Thu) | Comerica Park |
| Jun 27 | MIN | | 4 | 1 | | DET | Jun 27 07:10 PM EDT (Fri) | Comerica Park |
| Jun 28 | MIN | | 5 | 10 | | DET | Jun 28 01:10 PM EDT (Sat) | Comerica Park |
| Jun 29 | MIN | | 0 | 3 | | DET | Jun 29 07:10 PM EDT (Sun) | Comerica Park |
