| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Mar 27 | ATL |  | 4 | 7 |  | SD | Mar 27 04:10 PM EDT (Thu) | Petco Park |
| Mar 28 | ATL | | 3 | 4 | | SD | Mar 28 09:40 PM EDT (Fri) | Petco Park |
| Mar 29 | ATL | | 0 | 1 | | SD | Mar 29 07:15 PM EDT (Sat) | Petco Park |
| Mar 30 | ATL | | 0 | 5 | | SD | Mar 30 07:10 PM EDT (Sun) | Petco Park |
| Mar 31 | CLE |  | 2 | 7 | | SD | Mar 31 09:40 PM EDT (Mon) | Petco Park |
| Apr 01 | CLE | | 0 | 7 | | SD | Apr 01 09:40 PM EDT (Tue) | Petco Park |
| Apr 02 | CLE | | 2 | 5 | | SD | Apr 02 04:10 PM EDT (Wed) | Petco Park |
| Apr 04 | SD | | 1 | 3 |  | CHC | Apr 04 02:20 PM EDT (Fri) | Wrigley Field |
| Apr 05 | SD | | 1 | 7 | | CHC | Apr 05 02:20 PM EDT (Sat) | Wrigley Field |
| Apr 06 | SD | | 8 | 7 | | CHC | Apr 06 02:20 PM EDT (Sun) | Wrigley Field |
| Apr 07 | SD | | 5 | 4 |  | LV | Apr 07 10:05 PM EDT (Mon) | Sutter Health Park |
| Apr 08 | SD | | 4 | 10 | | LV | Apr 08 10:05 PM EDT (Tue) | Sutter Health Park |
| Apr 09 | SD | | 2 | 1 | | LV | Apr 09 03:35 PM EDT (Wed) | Sutter Health Park |
| Apr 11 | COL |  | 0 | 8 | | SD | Apr 11 09:40 PM EDT (Fri) | Petco Park |
| Apr 12 | COL | | 0 | 2 | | SD | Apr 12 08:40 PM EDT (Sat) | Petco Park |
| Apr 13 | COL | | 0 | 6 | | SD | Apr 13 04:10 PM EDT (Sun) | Petco Park |
| Apr 14 | CHC | | 4 | 10 | | SD | Apr 14 09:40 PM EDT (Mon) | Petco Park |
| Apr 15 | CHC | | 2 | 1 | | SD | Apr 15 09:40 PM EDT (Tue) | Petco Park |
| Apr 16 | CHC | | 2 | 4 | | SD | Apr 16 04:10 PM EDT (Wed) | Petco Park |
| Apr 18 | SD | | 4 | 6 |  | HOU | Apr 18 08:10 PM EDT (Fri) | Daikin Park |
| Apr 19 | SD | | 2 | 3 | | HOU | Apr 19 07:10 PM EDT (Sat) | Daikin Park |
| Apr 20 | SD | | 3 | 2 | | HOU | Apr 20 07:10 PM EDT (Sun) | Daikin Park |
| Apr 21 | SD | | 4 | 6 |  | DET | Apr 21 06:40 PM EDT (Mon) | Comerica Park |
| Apr 22 | SD | | 2 | 0 | | DET | Apr 22 06:40 PM EDT (Tue) | Comerica Park |
| Apr 23 | SD | | 0 | 6 | | DET | Apr 23 01:10 PM EDT (Wed) | Comerica Park |
| Apr 25 | TB |  | 1 | 0 | | SD | Apr 25 09:40 PM EDT (Fri) | Petco Park |
| Apr 26 | TB | | 4 | 1 | | SD | Apr 26 08:40 PM EDT (Sat) | Petco Park |
| Apr 27 | TB | | 4 | 2 | | SD | Apr 27 04:10 PM EDT (Sun) | Petco Park |
| Apr 29 | SF |  | 4 | 7 | | SD | Apr 29 09:40 PM EDT (Tue) | Petco Park |
| Apr 30 | SF | | 3 | 5 | | SD | Apr 30 04:10 PM EDT (Wed) | Petco Park |
| May 02 | SD | | 9 | 4 |  | PIT | May 02 06:40 PM EDT (Fri) | PNC Park |
| May 03 | SD | | 2 | 1 | | PIT | May 03 04:05 PM EDT (Sat) | PNC Park |
| May 04 | SD | | 4 | 0 | | PIT | May 04 01:35 PM EDT (Sun) | PNC Park |
| May 05 | SD | | 4 | 3 |  | NYY | May 05 07:05 PM EDT (Mon) | Yankee Stadium |
| May 06 | SD | | 3 | 12 | | NYY | May 06 07:05 PM EDT (Tue) | Yankee Stadium |
| May 07 | SD | | 3 | 4 | | NYY | May 07 07:05 PM EDT (Wed) | Yankee Stadium |
| May 09 | SD | | 13 | 9 | | COL | May 09 08:40 PM EDT (Fri) | Coors Field |
| May 10 | SD | | 21 | 0 | | COL | May 10 08:10 PM EDT (Sat) | Coors Field |
| May 11 | SD | | 3 | 9 | | COL | May 11 03:10 PM EDT (Sun) | Coors Field |
| May 12 | LAA |  | 9 | 5 | | SD | May 12 09:40 PM EDT (Mon) | Petco Park |
| May 13 | LAA | | 4 | 6 | | SD | May 13 09:40 PM EDT (Tue) | Petco Park |
| May 14 | LAA | | 1 | 5 | | SD | May 14 09:40 PM EDT (Wed) | Petco Park |
| May 16 | SEA |  | 5 | 1 | | SD | May 16 09:40 PM EDT (Fri) | Petco Park |
| May 17 | SEA | | 4 | 1 | | SD | May 17 08:40 PM EDT (Sat) | Petco Park |
| May 18 | SEA | | 6 | 1 | | SD | May 18 04:10 PM EDT (Sun) | Petco Park |
| May 20 | SD | | 0 | 3 |  | TOR | May 20 07:07 PM EDT (Tue) | Rogers Centre |
| May 21 | SD | | 0 | 14 | | TOR | May 21 07:07 PM EDT (Wed) | Rogers Centre |
| May 22 | SD | | 6 | 7 | | TOR | May 22 01:07 PM EDT (Thu) | Rogers Centre |
| May 23 | SD | | 2 | 1 | | ATL | May 23 07:15 PM EDT (Fri) | Truist Park |
| May 24 | SD | | 1 | 7 | | ATL | May 24 04:10 PM EDT (Sat) | Truist Park |
| May 25 | SD | | 5 | 3 | | ATL | May 25 04:10 PM EDT (Sun) | Truist Park |
| May 26 | MIA |  | 3 | 4 | | SD | May 26 08:40 PM EDT (Mon) | Petco Park |
| May 27 | MIA | | 6 | 8 | | SD | May 27 09:40 PM EDT (Tue) | Petco Park |
| May 28 | MIA | | 10 | 8 | | SD | May 28 04:10 PM EDT (Wed) | Petco Park |
| May 30 | PIT | | 2 | 3 | | SD | May 30 09:40 PM EDT (Fri) | Petco Park |
| May 31 | PIT | | 5 | 0 | | SD | May 31 09:40 PM EDT (Sat) | Petco Park |
| Jun 01 | PIT | | 4 | 6 | | SD | Jun 01 05:10 PM EDT (Sun) | Petco Park |
| Jun 02 | SD | | 1 | 0 | | SF | Jun 02 09:45 PM EDT (Mon) | Oracle Park |
| Jun 03 | SD | | 3 | 2 | | SF | Jun 03 09:45 PM EDT (Tue) | Oracle Park |
| Jun 04 | SD | | 5 | 6 | | SF | Jun 04 09:45 PM EDT (Wed) | Oracle Park |
| Jun 05 | SD | | 2 | 3 | | SF | Jun 05 03:45 PM EDT (Thu) | Oracle Park |
| Jun 06 | SD | | 2 | 0 |  | MIL | Jun 06 08:10 PM EDT (Fri) | American Family Field |
| Jun 07 | SD | | 3 | 4 | | MIL | Jun 07 07:35 PM EDT (Sat) | American Family Field |
| Jun 08 | SD | | 1 | 0 | | MIL | Jun 08 01:05 PM EDT (Sun) | American Family Field |
| Jun 09 | LAD |  | 8 | 7 | | SD | Jun 09 09:40 PM EDT (Mon) | Petco Park |
| Jun 10 | LAD | | 1 | 11 | | SD | Jun 10 09:40 PM EDT (Tue) | Petco Park |
| Jun 11 | LAD | | 5 | 2 | | SD | Jun 11 04:10 PM EDT (Wed) | Petco Park |
| Jun 13 | SD | | 1 | 5 |  | ARI | Jun 13 09:40 PM EDT (Fri) | Chase Field |
| Jun 14 | SD | | 7 | 8 | | ARI | Jun 14 07:15 PM EDT (Sat) | Chase Field |
| Jun 15 | SD | | 8 | 2 | | ARI | Jun 15 04:10 PM EDT (Sun) | Chase Field |
| Jun 16 | SD | | 3 | 6 | | LAD | Jun 16 10:10 PM EDT (Mon) | Dodger Stadium |
| Jun 17 | SD | | 6 | 8 | | LAD | Jun 17 10:10 PM EDT (Tue) | Dodger Stadium |
| Jun 18 | SD | | 3 | 4 | | LAD | Jun 18 10:10 PM EDT (Wed) | Dodger Stadium |
| Jun 19 | SD | | 5 | 3 | | LAD | Jun 19 10:10 PM EDT (Thu) | Dodger Stadium |
| Jun 20 | KC |  | 6 | 5 | | SD | Jun 20 09:40 PM EDT (Fri) | Petco Park |
| Jun 21 | KC | | 1 | 5 | | SD | Jun 21 07:15 PM EDT (Sat) | Petco Park |
| Jun 22 | KC | | 2 | 3 | | SD | Jun 22 04:10 PM EDT (Sun) | Petco Park |
| Jun 23 | WAS |  | 10 | 6 | | SD | Jun 23 09:40 PM EDT (Mon) | Petco Park |
| Jun 24 | WAS | | 3 | 4 | | SD | Jun 24 09:40 PM EDT (Tue) | Petco Park |
| Jun 25 | WAS | | 0 | 1 | | SD | Jun 25 04:10 PM EDT (Wed) | Petco Park |
| Jun 27 | SD | | 1 | 8 |  | CIN | Jun 27 07:10 PM EDT (Fri) | Great American Ball Park |
| Jun 28 | SD | | 6 | 4 | | CIN | Jun 28 04:10 PM EDT (Sat) | Great American Ball Park |
| Jun 29 | SD | | 2 | 3 | | CIN | Jun 29 01:40 PM EDT (Sun) | Great American Ball Park |
| Jun 30 | SD | | 0 | 4 |  | PHI | Jun 30 06:35 PM EDT (Mon) | Citizens Bank Park |
