| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 01 | DET |  | 4 | 1 |  | SEA | Apr 01 09:40 PM EDT (Tue) | T-Mobile Park |
| Apr 02 | DET | | 2 | 3 | | SEA | Apr 02 04:10 PM EDT (Wed) | T-Mobile Park |
| Apr 04 | CHW |  | 4 | 7 | | DET | Apr 04 01:10 PM EDT (Fri) | Comerica Park |
| Apr 05 | CHW | | 2 | 7 | | DET | Apr 05 01:10 PM EDT (Sat) | Comerica Park |
| Apr 06 | CHW | | 3 | 4 | | DET | Apr 06 01:40 PM EDT (Sun) | Comerica Park |
| Apr 07 | NYY |  | 2 | 6 | | DET | Apr 07 03:10 PM EDT (Mon) | Comerica Park |
| Apr 08 | NYY | | 0 | 5 | | DET | Apr 08 01:10 PM EDT (Tue) | Comerica Park |
| Apr 09 | NYY | | 4 | 3 | | DET | Apr 09 01:10 PM EDT (Wed) | Comerica Park |
| Apr 11 | DET | | 7 | 6 |  | MIN | Apr 11 08:10 PM EDT (Fri) | Target Field |
| Apr 12 | DET | | 4 | 0 | | MIN | Apr 12 02:10 PM EDT (Sat) | Target Field |
| Apr 13 | DET | | 1 | 5 | | MIN | Apr 13 02:10 PM EDT (Sun) | Target Field |
| Apr 14 | DET | | 9 | 1 |  | MIL | Apr 14 07:40 PM EDT (Mon) | American Family Field |
| Apr 15 | DET | | 0 | 5 | | MIL | Apr 15 07:40 PM EDT (Tue) | American Family Field |
| Apr 16 | DET | | 1 | 5 | | MIL | Apr 16 01:10 PM EDT (Wed) | American Family Field |
| Apr 17 | KC |  | 1 | 6 | | DET | Apr 17 06:40 PM EDT (Thu) | Comerica Park |
| Apr 18 | KC | | 3 | 7 | | DET | Apr 18 06:40 PM EDT (Fri) | Comerica Park |
| Apr 19 | KC | | 1 | 3 | | DET | Apr 19 01:10 PM EDT (Sat) | Comerica Park |
| Apr 20 | KC | | 4 | 3 | | DET | Apr 20 01:40 PM EDT (Sun) | Comerica Park |
| Apr 21 | SD |  | 4 | 6 | | DET | Apr 21 06:40 PM EDT (Mon) | Comerica Park |
| Apr 22 | SD | | 2 | 0 | | DET | Apr 22 06:40 PM EDT (Tue) | Comerica Park |
| Apr 23 | SD | | 0 | 6 | | DET | Apr 23 01:10 PM EDT (Wed) | Comerica Park |
| Apr 25 | BAL |  | (postponed) | | DET | Apr 25 06:10 PM EDT (Fri) | Comerica Park (resch Apr 26) |
| Apr 26 | BAL | | 3 | 4 | | DET | Apr 26 01:10 PM EDT (Sat) | Comerica Park |
| Apr 26 | BAL | | 2 | 6 | | DET | Apr 26 06:10 PM EDT (Sat) | Comerica Park |
| Apr 27 | BAL | | 0 | 7 | | DET | Apr 27 01:40 PM EDT (Sun) | Comerica Park |
| Apr 28 | DET | | 5 | 8 |  | HOU | Apr 28 08:10 PM EDT (Mon) | Daikin Park |
| Apr 29 | DET | | 4 | 6 | | HOU | Apr 29 08:10 PM EDT (Tue) | Daikin Park |
| Apr 30 | DET | | 7 | 4 | | HOU | Apr 30 02:10 PM EDT (Wed) | Daikin Park |
