| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 01 | CLE |  | 0 | 7 |  | SD | Apr 01 09:40 PM EDT (Tue) | Petco Park |
| Apr 02 | CLE | | 2 | 5 | | SD | Apr 02 04:10 PM EDT (Wed) | Petco Park |
| Apr 04 | SD | | 1 | 3 |  | CHC | Apr 04 02:20 PM EDT (Fri) | Wrigley Field |
| Apr 05 | SD | | 1 | 7 | | CHC | Apr 05 02:20 PM EDT (Sat) | Wrigley Field |
| Apr 06 | SD | | 8 | 7 | | CHC | Apr 06 02:20 PM EDT (Sun) | Wrigley Field |
| Apr 07 | SD | | 5 | 4 |  | LV | Apr 07 10:05 PM EDT (Mon) | Sutter Health Park |
| Apr 08 | SD | | 4 | 10 | | LV | Apr 08 10:05 PM EDT (Tue) | Sutter Health Park |
| Apr 09 | SD | | 2 | 1 | | LV | Apr 09 03:35 PM EDT (Wed) | Sutter Health Park |
| Apr 11 | COL |  | 0 | 8 | | SD | Apr 11 09:40 PM EDT (Fri) | Petco Park |
| Apr 12 | COL | | 0 | 2 | | SD | Apr 12 08:40 PM EDT (Sat) | Petco Park |
| Apr 13 | COL | | 0 | 6 | | SD | Apr 13 04:10 PM EDT (Sun) | Petco Park |
| Apr 14 | CHC | | 4 | 10 | | SD | Apr 14 09:40 PM EDT (Mon) | Petco Park |
| Apr 15 | CHC | | 2 | 1 | | SD | Apr 15 09:40 PM EDT (Tue) | Petco Park |
| Apr 16 | CHC | | 2 | 4 | | SD | Apr 16 04:10 PM EDT (Wed) | Petco Park |
| Apr 18 | SD | | 4 | 6 |  | HOU | Apr 18 08:10 PM EDT (Fri) | Daikin Park |
| Apr 19 | SD | | 2 | 3 | | HOU | Apr 19 07:10 PM EDT (Sat) | Daikin Park |
| Apr 20 | SD | | 3 | 2 | | HOU | Apr 20 07:10 PM EDT (Sun) | Daikin Park |
| Apr 21 | SD | | 4 | 6 |  | DET | Apr 21 06:40 PM EDT (Mon) | Comerica Park |
| Apr 22 | SD | | 2 | 0 | | DET | Apr 22 06:40 PM EDT (Tue) | Comerica Park |
| Apr 23 | SD | | 0 | 6 | | DET | Apr 23 01:10 PM EDT (Wed) | Comerica Park |
| Apr 25 | TB |  | 1 | 0 | | SD | Apr 25 09:40 PM EDT (Fri) | Petco Park |
| Apr 26 | TB | | 4 | 1 | | SD | Apr 26 08:40 PM EDT (Sat) | Petco Park |
| Apr 27 | TB | | 4 | 2 | | SD | Apr 27 04:10 PM EDT (Sun) | Petco Park |
| Apr 29 | SF |  | 4 | 7 | | SD | Apr 29 09:40 PM EDT (Tue) | Petco Park |
| Apr 30 | SF | | 3 | 5 | | SD | Apr 30 04:10 PM EDT (Wed) | Petco Park |
