| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Apr 01 | LAA |  | 9 | 7 |  | STL | Apr 01 07:45 PM EDT (Tue) | Busch Stadium |
| Apr 02 | LAA | | 5 | 12 | | STL | Apr 02 01:15 PM EDT (Wed) | Busch Stadium |
| Apr 04 | STL | | 9 | 13 |  | BOS | Apr 04 02:10 PM EDT (Fri) | Fenway Park |
| Apr 05 | STL | | (postponed) | | BOS | Apr 05 04:10 PM EDT (Sat) | Fenway Park (resch Apr 06) |
| Apr 06 | STL | | 4 | 5 | | BOS | Apr 06 01:35 PM EDT (Sun) | Fenway Park |
| Apr 06 | STL | | 7 | 18 | | BOS | Apr 06 07:10 PM EDT (Sun) | Fenway Park |
| Apr 07 | STL | | 4 | 8 |  | PIT | Apr 07 06:40 PM EDT (Mon) | PNC Park |
| Apr 08 | STL | | 5 | 3 | | PIT | Apr 08 06:40 PM EDT (Tue) | PNC Park |
| Apr 09 | STL | | 1 | 2 | | PIT | Apr 09 12:35 PM EDT (Wed) | PNC Park |
| Apr 11 | PHI |  | 0 | 2 | | STL | Apr 11 08:15 PM EDT (Fri) | Busch Stadium |
| Apr 12 | PHI | | 4 | 1 | | STL | Apr 12 02:15 PM EDT (Sat) | Busch Stadium |
| Apr 13 | PHI | | 0 | 7 | | STL | Apr 13 02:15 PM EDT (Sun) | Busch Stadium |
| Apr 14 | HOU |  | 3 | 8 | | STL | Apr 14 07:45 PM EDT (Mon) | Busch Stadium |
| Apr 15 | HOU | | 2 | 0 | | STL | Apr 15 07:45 PM EDT (Tue) | Busch Stadium |
| Apr 16 | HOU | | 1 | 4 | | STL | Apr 16 01:15 PM EDT (Wed) | Busch Stadium |
| Apr 17 | STL | | 1 | 4 |  | NYM | Apr 17 07:10 PM EDT (Thu) | Citi Field |
| Apr 18 | STL | | 4 | 5 | | NYM | Apr 18 07:10 PM EDT (Fri) | Citi Field |
| Apr 19 | STL | | 0 | 3 | | NYM | Apr 19 04:05 PM EDT (Sat) | Citi Field |
| Apr 20 | STL | | 4 | 7 | | NYM | Apr 20 01:40 PM EDT (Sun) | Citi Field |
| Apr 21 | STL | | 6 | 7 |  | ATL | Apr 21 07:15 PM EDT (Mon) | Truist Park |
| Apr 22 | STL | | 10 | 4 | | ATL | Apr 22 07:15 PM EDT (Tue) | Truist Park |
| Apr 23 | STL | | 1 | 4 | | ATL | Apr 23 12:15 PM EDT (Wed) | Truist Park |
| Apr 25 | MIL |  | 2 | 3 | | STL | Apr 25 08:15 PM EDT (Fri) | Busch Stadium |
| Apr 26 | MIL | | 5 | 6 | | STL | Apr 26 02:15 PM EDT (Sat) | Busch Stadium |
| Apr 27 | MIL | | 7 | 1 | | STL | Apr 27 02:15 PM EDT (Sun) | Busch Stadium |
| Apr 28 | STL | | 1 | 3 |  | CIN | Apr 28 06:40 PM EDT (Mon) | Great American Ball Park |
| Apr 29 | STL | | (postponed) | | CIN | Apr 29 12:40 PM EDT (Tue) | Great American Ball Park (resch Apr 30) |
| Apr 30 | STL | | 6 | 0 | | CIN | Apr 30 12:40 PM EDT (Wed) | Great American Ball Park |
| Apr 30 | STL | | 9 | 1 | | CIN | Apr 30 06:40 PM EDT (Wed) | Great American Ball Park |
