| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 01 | COL |  | 4 | 3 |  | SF | May 01 09:45 PM EDT (Thu) | Oracle Park |
| May 02 | COL | | 0 | 4 | | SF | May 02 10:15 PM EDT (Fri) | Oracle Park |
| May 03 | COL | | 3 | 6 | | SF | May 03 04:05 PM EDT (Sat) | Oracle Park |
| May 04 | COL | | 3 | 9 | | SF | May 04 04:05 PM EDT (Sun) | Oracle Park |
| May 06 | DET |  | (postponed) | | COL | May 06 08:40 PM EDT (Tue) | Coors Field (resch May 08) |
| May 07 | DET | | 8 | 6 | | COL | May 07 08:40 PM EDT (Wed) | Coors Field |
| May 08 | DET | | 10 | 2 | | COL | May 08 03:10 PM EDT (Thu) | Coors Field |
| May 08 | DET | | 11 | 1 | | COL | May 08 03:15 PM EDT (Thu) | Coors Field |
| May 09 | SD |  | 13 | 9 | | COL | May 09 08:40 PM EDT (Fri) | Coors Field |
| May 10 | SD | | 21 | 0 | | COL | May 10 08:10 PM EDT (Sat) | Coors Field |
| May 11 | SD | | 3 | 9 | | COL | May 11 03:10 PM EDT (Sun) | Coors Field |
| May 12 | COL | | 1 | 2 |  | TEX | May 12 08:05 PM EDT (Mon) | Globe Life Field |
| May 13 | COL | | 1 | 4 | | TEX | May 13 08:05 PM EDT (Tue) | Globe Life Field |
| May 14 | COL | | 3 | 8 | | TEX | May 14 08:05 PM EDT (Wed) | Globe Life Field |
| May 16 | COL | | 0 | 8 |  | ARI | May 16 09:40 PM EDT (Fri) | Chase Field |
| May 17 | COL | | 14 | 12 | | ARI | May 17 08:10 PM EDT (Sat) | Chase Field |
| May 18 | COL | | 0 | 1 | | ARI | May 18 04:10 PM EDT (Sun) | Chase Field |
| May 19 | PHI |  | 9 | 3 | | COL | May 19 08:40 PM EDT (Mon) | Coors Field |
| May 20 | PHI | | 7 | 4 | | COL | May 20 08:40 PM EDT (Tue) | Coors Field |
| May 21 | PHI | | 9 | 5 | | COL | May 21 08:40 PM EDT (Wed) | Coors Field |
| May 22 | PHI | | 2 | 0 | | COL | May 22 03:10 PM EDT (Thu) | Coors Field |
| May 23 | NYY |  | 2 | 3 | | COL | May 23 08:40 PM EDT (Fri) | Coors Field |
| May 24 | NYY | | 13 | 1 | | COL | May 24 04:10 PM EDT (Sat) | Coors Field |
| May 25 | NYY | | 5 | 4 | | COL | May 25 03:10 PM EDT (Sun) | Coors Field |
| May 26 | COL | | 1 | 3 |  | CHC | May 26 02:20 PM EDT (Mon) | Wrigley Field |
| May 27 | COL | | 3 | 4 | | CHC | May 27 08:05 PM EDT (Tue) | Wrigley Field |
| May 28 | COL | | 1 | 2 | | CHC | May 28 08:05 PM EDT (Wed) | Wrigley Field |
| May 30 | COL | | 2 | 4 |  | NYM | May 30 07:10 PM EDT (Fri) | Citi Field |
| May 31 | COL | | 2 | 8 | | NYM | May 31 04:10 PM EDT (Sat) | Citi Field |
