| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 02 | HOU |  | 3 | 7 |  | CHW | May 02 07:40 PM EDT (Fri) | Rate Field |
| May 03 | HOU | | 8 | 3 | | CHW | May 03 02:10 PM EDT (Sat) | Rate Field |
| May 04 | HOU | | 4 | 5 | | CHW | May 04 02:10 PM EDT (Sun) | Rate Field |
| May 05 | HOU | | 1 | 5 |  | MIL | May 05 07:40 PM EDT (Mon) | American Family Field |
| May 06 | HOU | | 3 | 4 | | MIL | May 06 07:40 PM EDT (Tue) | American Family Field |
| May 07 | HOU | | 9 | 1 | | MIL | May 07 01:10 PM EDT (Wed) | American Family Field |
| May 09 | CIN |  | 0 | 3 | | HOU | May 09 08:10 PM EDT (Fri) | Daikin Park |
| May 10 | CIN | | 13 | 9 | | HOU | May 10 07:10 PM EDT (Sat) | Daikin Park |
| May 11 | CIN | | 0 | 6 | | HOU | May 11 02:10 PM EDT (Sun) | Daikin Park |
| May 12 | KC |  | 7 | 5 | | HOU | May 12 08:10 PM EDT (Mon) | Daikin Park |
| May 13 | KC | | 1 | 2 | | HOU | May 13 08:10 PM EDT (Tue) | Daikin Park |
| May 14 | KC | | 3 | 4 | | HOU | May 14 08:10 PM EDT (Wed) | Daikin Park |
| May 15 | HOU | | 0 | 1 |  | TEX | May 15 08:05 PM EDT (Thu) | Globe Life Field |
| May 16 | HOU | | 6 | 3 | | TEX | May 16 08:05 PM EDT (Fri) | Globe Life Field |
| May 17 | HOU | | 1 | 5 | | TEX | May 17 07:05 PM EDT (Sat) | Globe Life Field |
| May 18 | HOU | | 4 | 3 | | TEX | May 18 01:05 PM EDT (Sun) | Globe Life Field |
| May 19 | HOU | | 4 | 3 |  | TB | May 19 07:05 PM EDT (Mon) | George M. Steinbrenner Field |
| May 20 | HOU | | 2 | 3 | | TB | May 20 07:05 PM EDT (Tue) | George M. Steinbrenner Field |
| May 21 | HOU | | 4 | 8 | | TB | May 21 01:10 PM EDT (Wed) | George M. Steinbrenner Field |
| May 22 | SEA |  | 2 | 9 | | HOU | May 22 08:10 PM EDT (Thu) | Daikin Park |
| May 23 | SEA | | 5 | 3 | | HOU | May 23 08:10 PM EDT (Fri) | Daikin Park |
| May 24 | SEA | | 1 | 2 | | HOU | May 24 04:10 PM EDT (Sat) | Daikin Park |
| May 25 | SEA | | 3 | 5 | | HOU | May 25 02:10 PM EDT (Sun) | Daikin Park |
| May 27 | LV |  | 1 | 11 | | HOU | May 27 08:10 PM EDT (Tue) | Daikin Park |
| May 28 | LV | | 3 | 5 | | HOU | May 28 02:10 PM EDT (Wed) | Daikin Park |
| May 29 | TB | | 13 | 3 | | HOU | May 29 08:10 PM EDT (Thu) | Daikin Park |
| May 30 | TB | | 1 | 2 | | HOU | May 30 08:10 PM EDT (Fri) | Daikin Park |
| May 31 | TB | | 16 | 3 | | HOU | May 31 04:10 PM EDT (Sat) | Daikin Park |
