| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 01 | CHC |  | 8 | 3 |  | PIT | May 01 12:35 PM EDT (Thu) | PNC Park |
| May 02 | SD |  | 9 | 4 | | PIT | May 02 06:40 PM EDT (Fri) | PNC Park |
| May 03 | SD | | 2 | 1 | | PIT | May 03 04:05 PM EDT (Sat) | PNC Park |
| May 04 | SD | | 4 | 0 | | PIT | May 04 01:35 PM EDT (Sun) | PNC Park |
| May 05 | PIT | | 3 | 6 |  | STL | May 05 07:45 PM EDT (Mon) | Busch Stadium |
| May 06 | PIT | | 1 | 2 | | STL | May 06 07:45 PM EDT (Tue) | Busch Stadium |
| May 07 | PIT | | 0 | 5 | | STL | May 07 01:15 PM EDT (Wed) | Busch Stadium |
| May 09 | ATL |  | 2 | 3 | | PIT | May 09 06:40 PM EDT (Fri) | PNC Park |
| May 10 | ATL | | 3 | 2 | | PIT | May 10 04:05 PM EDT (Sat) | PNC Park |
| May 11 | ATL | | 3 | 4 | | PIT | May 11 01:35 PM EDT (Sun) | PNC Park |
| May 12 | PIT | | 3 | 4 |  | NYM | May 12 07:10 PM EDT (Mon) | Citi Field |
| May 13 | PIT | | 1 | 2 | | NYM | May 13 07:10 PM EDT (Tue) | Citi Field |
| May 14 | PIT | | 4 | 0 | | NYM | May 14 07:10 PM EDT (Wed) | Citi Field |
| May 16 | PIT | | 4 | 8 |  | PHI | May 16 06:45 PM EDT (Fri) | Citizens Bank Park |
| May 17 | PIT | | 2 | 5 | | PHI | May 17 06:05 PM EDT (Sat) | Citizens Bank Park |
| May 18 | PIT | | 0 | 1 | | PHI | May 18 01:35 PM EDT (Sun) | Citizens Bank Park |
| May 19 | CIN |  | 7 | 1 | | PIT | May 19 06:40 PM EDT (Mon) | PNC Park |
| May 20 | CIN | | 0 | 1 | | PIT | May 20 06:40 PM EDT (Tue) | PNC Park |
| May 21 | CIN | | 1 | 3 | | PIT | May 21 12:35 PM EDT (Wed) | PNC Park |
| May 22 | MIL |  | 8 | 5 | | PIT | May 22 06:40 PM EDT (Thu) | PNC Park |
| May 23 | MIL | | 5 | 6 | | PIT | May 23 06:40 PM EDT (Fri) | PNC Park |
| May 24 | MIL | | 1 | 2 | | PIT | May 24 04:05 PM EDT (Sat) | PNC Park |
| May 25 | MIL | | 6 | 5 | | PIT | May 25 01:35 PM EDT (Sun) | PNC Park |
| May 26 | PIT | | 0 | 5 |  | ARI | May 26 08:10 PM EDT (Mon) | Chase Field |
| May 27 | PIT | | 9 | 6 | | ARI | May 27 09:40 PM EDT (Tue) | Chase Field |
| May 28 | PIT | | 10 | 1 | | ARI | May 28 03:40 PM EDT (Wed) | Chase Field |
| May 30 | PIT | | 2 | 3 | | SD | May 30 09:40 PM EDT (Fri) | Petco Park |
| May 31 | PIT | | 5 | 0 | | SD | May 31 09:40 PM EDT (Sat) | Petco Park |
