| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 02 | SEA |  | 13 | 1 |  | TEX | May 02 08:05 PM EDT (Fri) | Globe Life Field |
| May 03 | SEA | | 2 | 1 | | TEX | May 03 07:05 PM EDT (Sat) | Globe Life Field |
| May 04 | SEA | | 1 | 8 | | TEX | May 04 02:35 PM EDT (Sun) | Globe Life Field |
| May 05 | SEA | | 6 | 7 |  | LV | May 05 10:05 PM EDT (Mon) | Sutter Health Park |
| May 06 | SEA | | 5 | 3 | | LV | May 06 10:05 PM EDT (Tue) | Sutter Health Park |
| May 07 | SEA | | 6 | 5 | | LV | May 07 03:35 PM EDT (Wed) | Sutter Health Park |
| May 09 | TOR |  | 6 | 3 | | SEA | May 09 09:40 PM EDT (Fri) | T-Mobile Park |
| May 10 | TOR | | 6 | 3 | | SEA | May 10 09:40 PM EDT (Sat) | T-Mobile Park |
| May 11 | TOR | | 9 | 1 | | SEA | May 11 04:10 PM EDT (Sun) | T-Mobile Park |
| May 12 | NYY |  | 11 | 5 | | SEA | May 12 09:40 PM EDT (Mon) | T-Mobile Park |
| May 13 | NYY | | 1 | 2 | | SEA | May 13 09:40 PM EDT (Tue) | T-Mobile Park |
| May 14 | NYY | | 3 | 2 | | SEA | May 14 04:10 PM EDT (Wed) | T-Mobile Park |
| May 16 | SEA | | 5 | 1 |  | SD | May 16 09:40 PM EDT (Fri) | Petco Park |
| May 17 | SEA | | 4 | 1 | | SD | May 17 08:40 PM EDT (Sat) | Petco Park |
| May 18 | SEA | | 6 | 1 | | SD | May 18 04:10 PM EDT (Sun) | Petco Park |
| May 19 | SEA | | 5 | 1 |  | CHW | May 19 07:40 PM EDT (Mon) | Rate Field |
| May 20 | SEA | | 0 | 1 | | CHW | May 20 07:40 PM EDT (Tue) | Rate Field |
| May 21 | SEA | | 6 | 5 | | CHW | May 21 02:10 PM EDT (Wed) | Rate Field |
| May 22 | SEA | | 2 | 9 |  | HOU | May 22 08:10 PM EDT (Thu) | Daikin Park |
| May 23 | SEA | | 5 | 3 | | HOU | May 23 08:10 PM EDT (Fri) | Daikin Park |
| May 24 | SEA | | 1 | 2 | | HOU | May 24 04:10 PM EDT (Sat) | Daikin Park |
| May 25 | SEA | | 3 | 5 | | HOU | May 25 02:10 PM EDT (Sun) | Daikin Park |
| May 27 | WAS |  | 1 | 9 | | SEA | May 27 09:40 PM EDT (Tue) | T-Mobile Park |
| May 28 | WAS | | 9 | 0 | | SEA | May 28 09:40 PM EDT (Wed) | T-Mobile Park |
| May 29 | WAS | | 9 | 3 | | SEA | May 29 09:40 PM EDT (Thu) | T-Mobile Park |
| May 30 | MIN |  | 12 | 6 | | SEA | May 30 10:10 PM EDT (Fri) | T-Mobile Park |
| May 31 | MIN | | 4 | 5 | | SEA | May 31 07:15 PM EDT (Sat) | T-Mobile Park |
