| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Sep 01 | CLE |  | 4 | 6 |  | BOS | Sep 01 01:35 PM EDT (Mon) | Fenway Park |
| Sep 02 | CLE | | 7 | 11 | | BOS | Sep 02 06:45 PM EDT (Tue) | Fenway Park |
| Sep 03 | CLE | | 8 | 1 | | BOS | Sep 03 06:45 PM EDT (Wed) | Fenway Park |
| Sep 05 | BOS | | 5 | 10 |  | ARI | Sep 05 09:40 PM EDT (Fri) | Chase Field |
| Sep 06 | BOS | | 1 | 5 | | ARI | Sep 06 08:10 PM EDT (Sat) | Chase Field |
| Sep 07 | BOS | | 7 | 4 | | ARI | Sep 07 04:10 PM EDT (Sun) | Chase Field |
| Sep 08 | BOS | | 7 | 0 |  | LV | Sep 08 10:05 PM EDT (Mon) | Sutter Health Park |
| Sep 09 | BOS | | 6 | 0 | | LV | Sep 09 10:05 PM EDT (Tue) | Sutter Health Park |
| Sep 10 | BOS | | 4 | 5 | | LV | Sep 10 03:35 PM EDT (Wed) | Sutter Health Park |
| Sep 12 | NYY |  | 4 | 1 | | BOS | Sep 12 07:10 PM EDT (Fri) | Fenway Park |
| Sep 13 | NYY | | 5 | 3 | | BOS | Sep 13 04:10 PM EDT (Sat) | Fenway Park |
| Sep 14 | NYY | | 4 | 6 | | BOS | Sep 14 07:10 PM EDT (Sun) | Fenway Park |
| Sep 16 | LV | | 2 | 1 | | BOS | Sep 16 06:45 PM EDT (Tue) | Fenway Park |
| Sep 17 | LV | | 4 | 5 | | BOS | Sep 17 06:45 PM EDT (Wed) | Fenway Park |
| Sep 18 | LV | | 5 | 3 | | BOS | Sep 18 01:35 PM EDT (Thu) | Fenway Park |
| Sep 19 | BOS | | 11 | 7 |  | TB | Sep 19 07:35 PM EDT (Fri) | George M. Steinbrenner Field |
| Sep 20 | BOS | | 6 | 3 | | TB | Sep 20 07:05 PM EDT (Sat) | George M. Steinbrenner Field |
| Sep 21 | BOS | | 3 | 7 | | TB | Sep 21 07:35 PM EDT (Sun) | George M. Steinbrenner Field |
| Sep 23 | BOS | | 4 | 1 |  | TOR | Sep 23 07:07 PM EDT (Tue) | Rogers Centre |
| Sep 24 | BOS | | 7 | 1 | | TOR | Sep 24 07:07 PM EDT (Wed) | Rogers Centre |
| Sep 25 | BOS | | 1 | 6 | | TOR | Sep 25 07:07 PM EDT (Thu) | Rogers Centre |
| Sep 26 | DET |  | 3 | 4 | | BOS | Sep 26 07:10 PM EDT (Fri) | Fenway Park |
| Sep 27 | DET | | 2 | 1 | | BOS | Sep 27 04:10 PM EDT (Sat) | Fenway Park |
| Sep 28 | DET | | 3 | 4 | | BOS | Sep 28 03:05 PM EDT (Sun) | Fenway Park |
