| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Sep 01 | CLE |  | 4 | 6 |  | BOS | Sep 01 01:35 PM EDT (Mon) | Fenway Park |
| Sep 02 | CLE | | 7 | 11 | | BOS | Sep 02 06:45 PM EDT (Tue) | Fenway Park |
| Sep 03 | CLE | | 8 | 1 | | BOS | Sep 03 06:45 PM EDT (Wed) | Fenway Park |
| Sep 04 | CLE | | 2 | 4 |  | TB | Sep 04 07:35 PM EDT (Thu) | George M. Steinbrenner Field |
| Sep 05 | CLE | | 7 | 1 | | TB | Sep 05 07:35 PM EDT (Fri) | George M. Steinbrenner Field |
| Sep 06 | CLE | | 3 | 2 | | TB | Sep 06 07:05 PM EDT (Sat) | George M. Steinbrenner Field |
| Sep 07 | CLE | | 2 | 1 | | TB | Sep 07 12:10 PM EDT (Sun) | George M. Steinbrenner Field |
| Sep 08 | KC |  | 2 | 10 | | CLE | Sep 08 06:40 PM EDT (Mon) | Progressive Field |
| Sep 09 | KC | | 0 | 2 | | CLE | Sep 09 06:40 PM EDT (Tue) | Progressive Field |
| Sep 10 | KC | | 4 | 3 | | CLE | Sep 10 06:40 PM EDT (Wed) | Progressive Field |
| Sep 11 | KC | | 2 | 3 | | CLE | Sep 11 07:15 PM EDT (Thu) | Progressive Field |
| Sep 12 | CHW |  | 0 | 4 | | CLE | Sep 12 07:10 PM EDT (Fri) | Progressive Field |
| Sep 13 | CHW | | 1 | 3 | | CLE | Sep 13 06:10 PM EDT (Sat) | Progressive Field |
| Sep 14 | CHW | | 2 | 3 | | CLE | Sep 14 01:40 PM EDT (Sun) | Progressive Field |
| Sep 16 | CLE | | 7 | 5 |  | DET | Sep 16 06:40 PM EDT (Tue) | Comerica Park |
| Sep 17 | CLE | | 4 | 0 | | DET | Sep 17 06:40 PM EDT (Wed) | Comerica Park |
| Sep 18 | CLE | | 3 | 1 | | DET | Sep 18 01:10 PM EDT (Thu) | Comerica Park |
| Sep 19 | CLE | | 6 | 2 |  | MIN | Sep 19 08:10 PM EDT (Fri) | Target Field |
| Sep 20 | CLE | | 6 | 0 | | MIN | Sep 20 02:10 PM EDT (Sat) | Target Field |
| Sep 20 | CLE | | 8 | 0 | | MIN | Sep 20 07:10 PM EDT (Sat) | Target Field |
| Sep 21 | CLE | | 2 | 6 | | MIN | Sep 21 02:10 PM EDT (Sun) | Target Field |
| Sep 23 | DET | | 2 | 5 | | CLE | Sep 23 06:40 PM EDT (Tue) | Progressive Field |
| Sep 24 | DET | | 1 | 5 | | CLE | Sep 24 06:40 PM EDT (Wed) | Progressive Field |
| Sep 25 | DET | | 4 | 2 | | CLE | Sep 25 06:40 PM EDT (Thu) | Progressive Field |
| Sep 26 | TEX |  | 7 | 3 | | CLE | Sep 26 07:10 PM EDT (Fri) | Progressive Field |
| Sep 27 | TEX | | 2 | 3 | | CLE | Sep 27 07:15 PM EDT (Sat) | Progressive Field |
| Sep 28 | TEX | | 8 | 9 | | CLE | Sep 28 03:10 PM EDT (Sun) | Progressive Field |
