| Date | Away | | | | | Home | First Pitch | Where |
|---|
| Sep 01 | NYM |  | 10 | 8 |  | DET | Sep 01 01:10 PM EDT (Mon) | Comerica Park |
| Sep 02 | NYM | | 12 | 5 | | DET | Sep 02 06:40 PM EDT (Tue) | Comerica Park |
| Sep 03 | NYM | | 2 | 6 | | DET | Sep 03 01:10 PM EDT (Wed) | Comerica Park |
| Sep 05 | CHW |  | 7 | 5 | | DET | Sep 05 06:40 PM EDT (Fri) | Comerica Park |
| Sep 06 | CHW | | 0 | 6 | | DET | Sep 06 06:10 PM EDT (Sat) | Comerica Park |
| Sep 07 | CHW | | 6 | 4 | | DET | Sep 07 01:40 PM EDT (Sun) | Comerica Park |
| Sep 09 | DET | | 12 | 2 |  | NYY | Sep 09 07:05 PM EDT (Tue) | Yankee Stadium |
| Sep 10 | DET | | 11 | 1 | | NYY | Sep 10 07:05 PM EDT (Wed) | Yankee Stadium |
| Sep 11 | DET | | 3 | 9 | | NYY | Sep 11 07:05 PM EDT (Thu) | Yankee Stadium |
| Sep 12 | DET | | 2 | 8 |  | MIA | Sep 12 07:10 PM EDT (Fri) | loanDepot park |
| Sep 13 | DET | | 4 | 6 | | MIA | Sep 13 04:10 PM EDT (Sat) | loanDepot park |
| Sep 14 | DET | | 2 | 0 | | MIA | Sep 14 01:40 PM EDT (Sun) | loanDepot park |
| Sep 16 | CLE |  | 7 | 5 | | DET | Sep 16 06:40 PM EDT (Tue) | Comerica Park |
| Sep 17 | CLE | | 4 | 0 | | DET | Sep 17 06:40 PM EDT (Wed) | Comerica Park |
| Sep 18 | CLE | | 3 | 1 | | DET | Sep 18 01:10 PM EDT (Thu) | Comerica Park |
| Sep 19 | ATL |  | 10 | 1 | | DET | Sep 19 06:40 PM EDT (Fri) | Comerica Park |
| Sep 20 | ATL | | 6 | 5 | | DET | Sep 20 01:10 PM EDT (Sat) | Comerica Park |
| Sep 21 | ATL | | 6 | 2 | | DET | Sep 21 01:10 PM EDT (Sun) | Comerica Park |
| Sep 23 | DET | | 2 | 5 | | CLE | Sep 23 06:40 PM EDT (Tue) | Progressive Field |
| Sep 24 | DET | | 1 | 5 | | CLE | Sep 24 06:40 PM EDT (Wed) | Progressive Field |
| Sep 25 | DET | | 4 | 2 | | CLE | Sep 25 06:40 PM EDT (Thu) | Progressive Field |
| Sep 26 | DET | | 3 | 4 |  | BOS | Sep 26 07:10 PM EDT (Fri) | Fenway Park |
| Sep 27 | DET | | 2 | 1 | | BOS | Sep 27 04:10 PM EDT (Sat) | Fenway Park |
| Sep 28 | DET | | 3 | 4 | | BOS | Sep 28 03:05 PM EDT (Sun) | Fenway Park |
