| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 01 | BOS |  | 2 | 4 |  | TOR | May 01 07:07 PM EDT (Thu) | Rogers Centre |
| May 02 | MIN |  | 1 | 6 | | BOS | May 02 07:10 PM EDT (Fri) | Fenway Park |
| May 03 | MIN | | 4 | 3 | | BOS | May 03 04:10 PM EDT (Sat) | Fenway Park |
| May 04 | MIN | | 5 | 4 | | BOS | May 04 01:35 PM EDT (Sun) | Fenway Park |
| May 06 | TEX |  | 6 | 1 | | BOS | May 06 06:45 PM EDT (Tue) | Fenway Park |
| May 07 | TEX | | 4 | 6 | | BOS | May 07 06:45 PM EDT (Wed) | Fenway Park |
| May 08 | TEX | | 0 | 5 | | BOS | May 08 01:35 PM EDT (Thu) | Fenway Park |
| May 09 | BOS | | 1 | 2 |  | KC | May 09 07:40 PM EDT (Fri) | Kauffman Stadium |
| May 10 | BOS | | 10 | 1 | | KC | May 10 07:10 PM EDT (Sat) | Kauffman Stadium |
| May 11 | BOS | | 3 | 1 | | KC | May 11 02:10 PM EDT (Sun) | Kauffman Stadium |
| May 12 | BOS | | 2 | 14 |  | DET | May 12 06:40 PM EDT (Mon) | Comerica Park |
| May 13 | BOS | | 9 | 10 | | DET | May 13 06:40 PM EDT (Tue) | Comerica Park |
| May 14 | BOS | | 5 | 6 | | DET | May 14 06:40 PM EDT (Wed) | Comerica Park |
| May 16 | ATL |  | 4 | 2 | | BOS | May 16 07:10 PM EDT (Fri) | Fenway Park |
| May 17 | ATL | | 6 | 7 | | BOS | May 17 07:15 PM EDT (Sat) | Fenway Park |
| May 18 | ATL | | 10 | 4 | | BOS | May 18 01:35 PM EDT (Sun) | Fenway Park |
| May 19 | NYM |  | 1 | 3 | | BOS | May 19 06:45 PM EDT (Mon) | Fenway Park |
| May 20 | NYM | | 0 | 2 | | BOS | May 20 06:45 PM EDT (Tue) | Fenway Park |
| May 21 | NYM | | 5 | 1 | | BOS | May 21 06:45 PM EDT (Wed) | Fenway Park |
| May 22 | BAL |  | (postponed) | | BOS | May 22 06:45 PM EDT (Thu) | Fenway Park (resch May 23) |
| May 23 | BAL | | 5 | 19 | | BOS | May 23 01:35 PM EDT (Fri) | Fenway Park |
| May 23 | BAL | | (postponed) | | BOS | May 23 07:10 PM EDT (Fri) | Fenway Park (resch May 24) |
| May 24 | BAL | | 5 | 6 | | BOS | May 24 01:05 PM EDT (Sat) | Fenway Park |
| May 24 | BAL | | 2 | 1 | | BOS | May 24 06:35 PM EDT (Sat) | Fenway Park |
| May 25 | BAL | | 5 | 1 | | BOS | May 25 01:35 PM EDT (Sun) | Fenway Park |
| May 26 | BOS | | 2 | 3 |  | MIL | May 26 02:10 PM EDT (Mon) | American Family Field |
| May 27 | BOS | | 1 | 5 | | MIL | May 27 07:40 PM EDT (Tue) | American Family Field |
| May 28 | BOS | | 5 | 6 | | MIL | May 28 01:10 PM EDT (Wed) | American Family Field |
| May 30 | BOS | | 5 | 1 | | ATL | May 30 07:15 PM EDT (Fri) | Truist Park |
| May 31 | BOS | | 0 | 5 | | ATL | May 31 04:10 PM EDT (Sat) | Truist Park |
