| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 01 | MIN |  | 3 | 4 |  | CLE | May 01 01:10 PM EDT (Thu) | Progressive Field |
| May 02 | CLE | | 3 | 5 |  | TOR | May 02 07:07 PM EDT (Fri) | Rogers Centre |
| May 03 | CLE | | 5 | 3 | | TOR | May 03 03:07 PM EDT (Sat) | Rogers Centre |
| May 04 | CLE | | 5 | 4 | | TOR | May 04 01:37 PM EDT (Sun) | Rogers Centre |
| May 05 | CLE | | (postponed) |  | WAS | May 05 06:45 PM EDT (Mon) | Nationals Park (resch May 06) |
| May 06 | CLE | | 9 | 10 | | WAS | May 06 03:35 PM EDT (Tue) | Nationals Park |
| May 06 | CLE | | 9 | 1 | | WAS | May 06 03:40 PM EDT (Tue) | Nationals Park |
| May 07 | CLE | | 8 | 6 | | WAS | May 07 12:05 PM EDT (Wed) | Nationals Park |
| May 09 | PHI |  | 0 | 6 | | CLE | May 09 07:10 PM EDT (Fri) | Progressive Field |
| May 10 | PHI | | 7 | 1 | | CLE | May 10 06:10 PM EDT (Sat) | Progressive Field |
| May 11 | PHI | | 3 | 0 | | CLE | May 11 07:10 PM EDT (Sun) | Progressive Field |
| May 12 | MIL |  | 0 | 5 | | CLE | May 12 06:10 PM EDT (Mon) | Progressive Field |
| May 13 | MIL | | 0 | 2 | | CLE | May 13 06:10 PM EDT (Tue) | Progressive Field |
| May 14 | MIL | | 9 | 5 | | CLE | May 14 01:10 PM EDT (Wed) | Progressive Field |
| May 16 | CLE | | 4 | 5 |  | CIN | May 16 05:10 PM EDT (Fri) | Great American Ball Park |
| May 17 | CLE | | 1 | 4 | | CIN | May 17 06:40 PM EDT (Sat) | Great American Ball Park |
| May 18 | CLE | | 1 | 3 | | CIN | May 18 01:40 PM EDT (Sun) | Great American Ball Park |
| May 19 | CLE | | 5 | 6 | | MIN | May 19 07:40 PM EDT (Mon) | Target Field |
| May 20 | CLE | | (postponed) | | MIN | May 20 07:40 PM EDT (Tue) | Target Field (resch Sep 20) |
| May 21 | CLE | | 5 | 1 | | MIN | May 21 03:55 PM EDT (Wed) | Target Field |
| May 22 | CLE | | 7 | 0 |  | DET | May 22 06:40 PM EDT (Thu) | Comerica Park |
| May 23 | CLE | | 3 | 1 | | DET | May 23 07:10 PM EDT (Fri) | Comerica Park |
| May 24 | CLE | | 7 | 5 | | DET | May 24 07:15 PM EDT (Sat) | Comerica Park |
| May 25 | CLE | | 0 | 5 | | DET | May 25 11:35 AM EDT (Sun) | Comerica Park |
| May 26 | LAD |  | 7 | 2 | | CLE | May 26 06:10 PM EDT (Mon) | Progressive Field |
| May 27 | LAD | | 9 | 5 | | CLE | May 27 06:10 PM EDT (Tue) | Progressive Field |
| May 28 | LAD | | 4 | 7 | | CLE | May 28 01:10 PM EDT (Wed) | Progressive Field |
| May 30 | LAA |  | 4 | 1 | | CLE | May 30 07:10 PM EDT (Fri) | Progressive Field |
| May 31 | LAA | | 5 | 7 | | CLE | May 31 04:10 PM EDT (Sat) | Progressive Field |
