| Date | Away | | | | | Home | First Pitch | Where |
|---|
| May 02 | SD |  | 9 | 4 |  | PIT | May 02 06:40 PM EDT (Fri) | PNC Park |
| May 03 | SD | | 2 | 1 | | PIT | May 03 04:05 PM EDT (Sat) | PNC Park |
| May 04 | SD | | 4 | 0 | | PIT | May 04 01:35 PM EDT (Sun) | PNC Park |
| May 05 | SD | | 4 | 3 |  | NYY | May 05 07:05 PM EDT (Mon) | Yankee Stadium |
| May 06 | SD | | 3 | 12 | | NYY | May 06 07:05 PM EDT (Tue) | Yankee Stadium |
| May 07 | SD | | 3 | 4 | | NYY | May 07 07:05 PM EDT (Wed) | Yankee Stadium |
| May 09 | SD | | 13 | 9 |  | COL | May 09 08:40 PM EDT (Fri) | Coors Field |
| May 10 | SD | | 21 | 0 | | COL | May 10 08:10 PM EDT (Sat) | Coors Field |
| May 11 | SD | | 3 | 9 | | COL | May 11 03:10 PM EDT (Sun) | Coors Field |
| May 12 | LAA |  | 9 | 5 | | SD | May 12 09:40 PM EDT (Mon) | Petco Park |
| May 13 | LAA | | 4 | 6 | | SD | May 13 09:40 PM EDT (Tue) | Petco Park |
| May 14 | LAA | | 1 | 5 | | SD | May 14 09:40 PM EDT (Wed) | Petco Park |
| May 16 | SEA |  | 5 | 1 | | SD | May 16 09:40 PM EDT (Fri) | Petco Park |
| May 17 | SEA | | 4 | 1 | | SD | May 17 08:40 PM EDT (Sat) | Petco Park |
| May 18 | SEA | | 6 | 1 | | SD | May 18 04:10 PM EDT (Sun) | Petco Park |
| May 20 | SD | | 0 | 3 |  | TOR | May 20 07:07 PM EDT (Tue) | Rogers Centre |
| May 21 | SD | | 0 | 14 | | TOR | May 21 07:07 PM EDT (Wed) | Rogers Centre |
| May 22 | SD | | 6 | 7 | | TOR | May 22 01:07 PM EDT (Thu) | Rogers Centre |
| May 23 | SD | | 2 | 1 |  | ATL | May 23 07:15 PM EDT (Fri) | Truist Park |
| May 24 | SD | | 1 | 7 | | ATL | May 24 04:10 PM EDT (Sat) | Truist Park |
| May 25 | SD | | 5 | 3 | | ATL | May 25 04:10 PM EDT (Sun) | Truist Park |
| May 26 | MIA |  | 3 | 4 | | SD | May 26 08:40 PM EDT (Mon) | Petco Park |
| May 27 | MIA | | 6 | 8 | | SD | May 27 09:40 PM EDT (Tue) | Petco Park |
| May 28 | MIA | | 10 | 8 | | SD | May 28 04:10 PM EDT (Wed) | Petco Park |
| May 30 | PIT | | 2 | 3 | | SD | May 30 09:40 PM EDT (Fri) | Petco Park |
| May 31 | PIT | | 5 | 0 | | SD | May 31 09:40 PM EDT (Sat) | Petco Park |
